Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.43 |
| ▸ | RXRA | P19793 | 5/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3473999 | 0.93 | CHRNA7 (0.44) | CHRNA7MALT1NR1H2RXRANR1H3 | |
| SCHEMBL3471432 | 0.82 | EPHX2 (0.47) | MALT1NR1H2RXRANR1H3HSD11B1 | |
| SCHEMBL3473402 | 0.82 | PTGS1 (0.45) | MALT1NR1H2RXRANR1H3HSD11B1 | |
| SCHEMBL3471856 | 0.82 | NR1H2 (0.44) | MALT1NR1H2RXRANR1H3HSD11B1 | |
| SCHEMBL3472957 | 0.82 | NR1H2 (0.47) | NR1H2RXRANR1H3HSD11B1 | |
| SCHEMBL3470697 | 0.82 | RXRA (0.47) | CHRNA7MALT1NR1H2RXRANR1H3 | |
| SCHEMBL3472174 | 0.80 | NR1H2 (0.46) | MALT1NR1H2RXRANR1H3PTGS2 | |
| SCHEMBL3472981 | 0.79 | NR1H2 (0.44) | NR1H2RXRANR1H3CNR1 | |
| SCHEMBL3472767 | 0.79 | NR1H2 (0.45) | MALT1NR1H2RXRANR1H3 | |
| SCHEMBL2256963 | 0.79 | NR1H2 (0.59) | NR1H2RXRANR1H3HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331295-A1 | MODULATORS OF LXR | NR1H2, NR1H3, NR1H4 | CHRNA7 704/4885MALT1 2992/4885NR1H2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.