Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 4/20 | 0.54 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.44 |
| ▸ | RXRA | P19793 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESRRG | P62508 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3472078 | 1.00 | HSD17B1 (0.54) | HSD17B1HSD17B2HDAC6HSD11B1HDAC1 | |
| SCHEMBL3472072 | 1.00 | HSD17B1 (0.54) | HSD17B1HSD17B2HDAC6HSD11B1HDAC1 | |
| SCHEMBL12978665 | 0.86 | HDAC6 (0.65) | HSD17B1HSD17B2HDAC6HSD11B1HDAC1 | |
| SCHEMBL3471160 | 0.79 | HSD17B1 (0.60) | HSD17B1HSD17B2HDAC6HSD11B1CNR1 | |
| SCHEMBL3472354 | 0.79 | HSD17B1 (0.54) | HSD17B1HSD17B2HDAC6HSD11B1HDAC1 | |
| SCHEMBL14623234 | 0.76 | HSD17B1 (0.46) | HSD17B1HSD17B2HDAC6HSD11B1HDAC1 | |
| SCHEMBL27716967 | 0.76 | HSD17B1 (0.57) | HSD17B1HSD17B2HDAC6HSD11B1CNR1 | |
| SCHEMBL12979313 | 0.75 | HSD17B1 (0.53) | HSD17B1HSD17B2HSD11B1CNR1NR1H2 | |
| SCHEMBL16328672 | 0.73 | HSD17B1 (0.42) | HSD17B1HSD17B2HDAC6HDAC1CNR1 | |
| SCHEMBL16328673 | 0.73 | HSD17B1 (0.44) | HSD17B1HSD17B2HDAC6HDAC1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331295-A1 | MODULATORS OF LXR | NR1H2, NR1H3, NR1H4 | HSD17B1 148/4885HSD17B2 241/4885HDAC6 1826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.