Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 6/20 | 0.70 |
| ▸ | RXRA | P19793 | 5/20 | 0.70 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.40 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.40 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27716917 | 0.85 | RXRA (0.55) | NR1H2RXRANR1H3KCNH2SLC16A3 | |
| SCHEMBL3472983 | 0.83 | RXRA (0.69) | NR1H2RXRANR1H3KCNH2SLC16A3 | |
| SCHEMBL3474695 | 0.82 | NR1H2 (0.70) | NR1H2RXRANR1H3KCNH2SMN1; SMN2 | |
| SCHEMBL3475403 | 0.82 | NR1H2 (0.58) | NR1H2RXRANR1H3KCNH2SMN1; SMN2 | |
| SCHEMBL3470760 | 0.82 | NR1H2 (1.00) | NR1H2RXRANR1H3KCNH2SMN1; SMN2 | |
| SCHEMBL15229742 | 0.82 | NR1H2 (0.77) | NR1H2RXRANR1H3KCNH2SMN1; SMN2 | |
| SCHEMBL15229903 | 0.81 | NR1H2 (0.71) | NR1H2RXRANR1H3SMN1; SMN2SLC16A3 | |
| SCHEMBL16455590 | 0.80 | NR1H2 (0.71) | NR1H2RXRANR1H3SMN1; SMN2SLC16A3 | |
| SCHEMBL3474615 | 0.80 | NR1H2 (0.71) | NR1H2RXRANR1H3KCNH2SMN1; SMN2 | |
| SCHEMBL3472319 | 0.80 | RXRA (0.57) | NR1H2RXRANR1H3KCNH2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| EP-1910307-A1 | PYRAZOLE BASED LXR MODULATORS | Exelixis, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007002559-A1 | PYRAZOLE BASED LXR MODULATORS | EXELIXIS, INC. (US) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331295-A1 | MODULATORS OF LXR | NR1H2, NR1H3, NR1H4 | NR1H2 1/4885RXRA 18/4885NR1H3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.