Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 4/20 | 0.50 |
| ▸ | HTR1A | P08908 | 9/20 | 0.48 |
| ▸ | DRD4 | P21917 | 9/20 | 0.48 |
| ▸ | DRD2 | P14416 | 7/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | IDH2 | P48735 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2327562 | 0.92 | DRD4 (0.50) | IDH1HTR1ADRD4DRD2KCNH2 | |
| SCHEMBL31608532 | 0.92 | DRD4 (0.50) | IDH1HTR1ADRD4DRD2KCNH2 | |
| SCHEMBL4575297 | 0.84 | HTR2C (0.47) | IDH1HTR1ADRD4DRD2KCNH2 | |
| SCHEMBL15649468 | 0.82 | HTR2A (0.44) | IDH1DRD2IDH2 | |
| SCHEMBL21037509 | 0.82 | DRD4 (0.58) | IDH1HTR1ADRD4DRD2KCNH2 | |
| SCHEMBL19625288 | 0.80 | CNR2 (0.47) | HTR1ADRD4DRD2KCNH2TLR8 | |
| SCHEMBL14683803 | 0.78 | HTR2C (0.42) | IDH1HTR1ADRD4DRD2KCNH2 | |
| SCHEMBL18965245 | 0.78 | DRD4 (0.52) | IDH1HTR1ADRD4DRD2KCNH2 | |
| SCHEMBL22543808 | 0.78 | CNR2 (0.42) | IDH1HTR1ADRD4DRD2KCNH2 | |
| SCHEMBL24565129 | 0.78 | HTR1A (0.53) | HTR1ADRD2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010130943-A1 | 5-MEMBERED HETEROCYCLIC COMPOUND CYCLOPENTA[C]PYRROLYLALKYLCARBAMATE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-11-18 | — | — | WO | disclosed |