Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | APAF1 | O14727 | 3/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GLA | P06280 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3476243 | 0.83 | MAPT (0.46) | MAPTSMN1; SMN2APAF1SENP7SENP6 | |
| SCHEMBL2774055 | 0.83 | MAPT (0.43) | HDAC1HDAC6MAPTSMN1; SMN2APAF1 | |
| SCHEMBL3477405 | 0.81 | GAA (0.46) | MAPTSMN1; SMN2APAF1SENP7SENP6 | |
| SCHEMBL2791335 | 0.80 | MAPT (0.44) | HDAC1HDAC6MAPTSMN1; SMN2APAF1 | |
| SCHEMBL3475910 | 0.79 | HDAC1 (0.41) | HDAC1HDAC6MAPTSMN1; SMN2APAF1 | |
| SCHEMBL2773622 | 0.77 | HRH4 (0.44) | MAPTSMN1; SMN2APAF1SENP7SENP6 | |
| SCHEMBL2773055 | 0.77 | SENP6 (0.49) | HDAC1MAPTSMN1; SMN2APAF1SENP7 | |
| SCHEMBL2775160 | 0.76 | HRH4 (0.43) | MAPTSMN1; SMN2APAF1SENP7SENP6 | |
| SCHEMBL2787353 | 0.76 | CNR1 (0.46) | MAPTSMN1; SMN2GAAALDH1A1HTT | |
| SCHEMBL2775659 | 0.76 | MAPT (0.39) | HDAC1HDAC6MAPTSMN1; SMN2APAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010130900-A2 | TRIAMINOPYRIMIDINE DERIVATIVES AS CDC25 PHOSPHATASE INHIBITORS | IPSEN PHARMA S.A.S. (FR) | 2010-11-18 | — | — | WO | claimed |
| WO-2010130900-A2 | TRIAMINOPYRIMIDINE DERIVATIVES AS CDC25 PHOSPHATASE INHIBITORS | IPSEN PHARMA S.A.S. (FR) | 2010-11-18 | — | — | WO | disclosed |