Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 8/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 2/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7812927 | 0.84 | GRM2 (0.33) | GRM2 | |
| SCHEMBL3476240 | 0.83 | GRM2 (0.39) | GRM2 | |
| SCHEMBL3476386 | 0.82 | GRM2 (0.48) | GRM2 | |
| SCHEMBL3475357 | 0.82 | GRM2 (0.43) | GRM2GRM5 | |
| SCHEMBL3475398 | 0.79 | GRM2 (0.33) | GRM2AR | |
| SCHEMBL3475411 | 0.78 | GRM2 (0.42) | GRM2AR | |
| SCHEMBL3475355 | 0.75 | GRM2 (0.35) | GRM2 | |
| SCHEMBL3476696 | 0.73 | GRM2 (0.37) | GRM2EGLN2AR | |
| SCHEMBL3476662 | 0.73 | GRM2 (0.35) | GRM2 | |
| SCHEMBL9898199 | 0.72 | GRM2 (0.35) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | claimed |
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | disclosed |