Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12886723 | 0.94 | ALDH1A1 (0.46) | ALDH1A1CYP3A4CA2MAPK1TSHR | |
| SCHEMBL13141996 | 0.90 | TAAR1 (0.47) | ALDH1A1CYP3A4HTR2ACA2MAPK1 | |
| SCHEMBL666868 | 0.87 | HTR2A (0.43) | CYP3A4HTR2AL3MBTL1 | |
| SCHEMBL7745907 | 0.87 | HTR2A (0.40) | ALDH1A1CYP3A4HTR2ACA2MAPK1 | |
| SCHEMBL1031784 | 0.87 | HTR2A (0.40) | ALDH1A1CYP3A4HTR2ACA2MAPK1 | |
| SCHEMBL7743891 | 0.87 | HTR2A (0.40) | ALDH1A1CYP3A4HTR2ACA2MAPK1 | |
| SCHEMBL6763498 | 0.83 | HTR2A (0.37) | ALDH1A1CYP3A4HTR2ACA2MAPK1 | |
| SCHEMBL23201542 | 0.83 | CYP3A4 (0.47) | ALDH1A1CYP3A4CA2MAPK1TSHR | |
| SCHEMBL10375177 | 0.83 | CYP3A4 (0.43) | ALDH1A1CYP3A4CA2MAPK1TSHR | |
| SCHEMBL7561582 | 0.80 | CYP3A4 (0.44) | ALDH1A1CYP3A4HTR2ACA2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140357806-A1 | THERMAL-RESPONSIVE POLYMER NETWORKS, COMPOSITIONS, AND METHODS AND APPLICATIONS RELATED THERETO | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL (US) | 2014-12-04 | — | — | US | disclosed |
| US-8597630-B2 | Thermal-responsive polymer networks, compositions, and methods and applications related thereto | UNIVERSITY OF MASSACHUSETTS (US) | 2013-12-03 | — | — | US | disclosed |
| US-20100280561-A1 | Thermal-Responsive Polymer Networks, Compositions, And Methods And Applications Related Thereto | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 2010-11-04 | — | — | US | disclosed |