Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 7/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | HPGDS | O60760 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7810660 | 0.87 | GRM2 (0.39) | GRM2PDE10A | |
| SCHEMBL3475691 | 0.87 | CNR2 (0.38) | GRM2PDE10A | |
| SCHEMBL3475397 | 0.86 | GRM2 (0.36) | GRM2 | |
| SCHEMBL7816241 | 0.86 | GRM2 (0.40) | GRM2SLC22A12 | |
| SCHEMBL15625099 | 0.84 | GRM2 (0.35) | GRM2 | |
| SCHEMBL3476696 | 0.84 | GRM2 (0.37) | GRM2PDE10A | |
| SCHEMBL3469755 | 0.83 | CNR1 (0.37) | GRM2SLC22A12 | |
| SCHEMBL3475915 | 0.82 | DYRK1A (0.35) | GRM2 | |
| SCHEMBL3475638 | 0.82 | GRM2 (0.37) | GRM2SLC22A12 | |
| SCHEMBL13728821 | 0.82 | MAPK1 (0.37) | GRM2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | claimed |
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | disclosed |
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | disclosed |