Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 6/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | ATR | Q13535 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3476138 | 0.86 | GRM2 (0.38) | GRM2 | |
| SCHEMBL7810660 | 0.85 | GRM2 (0.39) | GRM2ATM | |
| SCHEMBL3475691 | 0.85 | CNR2 (0.38) | GRM2 | |
| SCHEMBL3476175 | 0.84 | CSNK1D (0.36) | GRM2S1PR1 | |
| SCHEMBL7816241 | 0.84 | GRM2 (0.40) | GRM2 | |
| SCHEMBL3476696 | 0.82 | GRM2 (0.37) | GRM2 | |
| SCHEMBL15625099 | 0.82 | GRM2 (0.35) | GRM2 | |
| SCHEMBL7819300 | 0.82 | GRM2 (0.39) | GRM2 | |
| SCHEMBL3474766 | 0.82 | GRM2 (0.39) | GRM2 | |
| SCHEMBL3475817 | 0.81 | GRM2 (0.36) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | claimed |
| US-8785482-B2 | Cyclohexene benzotriazole derivatives | MERCK SHARP & DOHME CORP. (US) | 2014-07-22 | — | — | US | disclosed |
| US-8785482-B2 | Cyclohexene benzotriazole derivatives | MERCK SHARP & DOHME CORP. (US) | 2014-07-22 | — | — | US | disclosed |
| US-8785482-B2 | Cyclohexene benzotriazole derivatives | MERCK SHARP & DOHME CORP. (US) | 2014-07-22 | — | — | US | disclosed |
| US-20140088150-A1 | CYCLOHEXENE BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LLC | 2014-03-27 | — | — | US | disclosed |
| US-20140088150-A1 | CYCLOHEXENE BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LLC | 2014-03-27 | — | — | US | disclosed |
| US-20140088150-A1 | CYCLOHEXENE BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LLC | 2014-03-27 | — | — | US | disclosed |
| EP-2704574-A1 | CYCLOHEXENE BENZOTRIAZOLE DERIVATIVES | Merck Sharp & Dohme Corp. (US) | 2014-03-12 | — | — | EP | disclosed |
| WO-2012151138-A1 | CYCLOHEXENE BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-11-08 | — | — | WO | disclosed |
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | disclosed |
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140088150-A1 | CYCLOHEXENE BENZOTRIAZOLE DERIVATIVES | GRM2, GRIA2, GRIK2 | GRM2 1/4885S1PR1 1333/4885KCNH2 1704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.