Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.74 |
| ▸ | MTOR | P42345 | 7/20 | 0.74 |
| ▸ | KDR | P35968 | 6/20 | 0.53 |
| ▸ | FLT3 | P36888 | 6/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL406625 | 0.89 | PIK3CA (0.75) | PIK3CAMTORKDRFLT3 | |
| SCHEMBL407547 | 0.85 | PIK3CA (1.00) | PIK3CAMTORKDRFLT3 | |
| SCHEMBL406624 | 0.75 | PIK3CA (1.00) | PIK3CAMTORKDRFLT3 | |
| SCHEMBL380381 | 0.71 | PIK3CA (1.00) | PIK3CAMTOR | |
| SCHEMBL5251631 | 0.70 | KDR (1.00) | KDRFLT3 | |
| SCHEMBL5248501 | 0.70 | KDR (1.00) | KDRFLT3 | |
| SCHEMBL17556158 | 0.70 | KDR (0.69) | PIK3CAMTORKDRFLT3 | |
| SCHEMBL3199909 | 0.69 | KDR (0.64) | PIK3CAMTORKDRFLT3 | |
| SCHEMBL409921 | 0.69 | PIK3CA (0.74) | PIK3CAMTOR | |
| SCHEMBL381071 | 0.69 | PIK3CA (1.00) | PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010108074-A2 | INHIBITORS OF PI3 KINASE | AMGEN INC. (US) | 2010-09-23 | — | — | WO | disclosed |