Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.75 |
| ▸ | MTOR | P42345 | 7/20 | 0.75 |
| ▸ | KDR | P35968 | 6/20 | 0.55 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 4/20 | 0.49 |
| ▸ | NEK2 | P51955 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3476586 | 0.89 | PIK3CA (0.74) | PIK3CAMTORKDRFLT3 | |
| SCHEMBL406624 | 0.86 | PIK3CA (1.00) | PIK3CAMTORKDRGABRG2GABRB3 | |
| SCHEMBL380520 | 0.80 | PIK3CA (1.00) | PIK3CAMTORKDRGABRG2GABRB3 | |
| SCHEMBL7900395 | 0.76 | PIK3CA (0.72) | PIK3CAMTORKDRGABRG2GABRB3 | |
| SCHEMBL407547 | 0.74 | PIK3CA (1.00) | PIK3CAMTORKDRFLT3FGFR3 | |
| SCHEMBL5251547 | 0.72 | KDR (1.00) | PIK3CAMTORKDRGABRG2GABRB3 | |
| SCHEMBL16588365 | 0.72 | GABRG2 (0.83) | PIK3CAMTORKDRGABRG2GABRB3 | |
| SCHEMBL14144255 | 0.70 | KDR (0.80) | PIK3CAMTORKDRGABRG2GABRB3 | |
| SCHEMBL3196127 | 0.70 | KDR (0.71) | PIK3CAMTORKDRGABRG2GABRB3 | |
| SCHEMBL14144197 | 0.69 | KDR (0.70) | PIK3CAMTORKDRGABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408773-A2 | INHIBITORS OF PI3 KINASE | Amgen, Inc (US) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010108074-A2 | INHIBITORS OF PI3 KINASE | AMGEN INC. (US) | 2010-09-23 | — | — | WO | disclosed |