Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.64 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.56 |
| ▸ | FAAH | O00519 | 2/20 | 0.56 |
| ▸ | IL6 | P05231 | 1/20 | 0.53 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | VCP | P55072 | 1/20 | 0.49 |
| ▸ | RHOA | P61586 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3475414 | 0.91 | HDAC6 (0.61) | HDAC6DGAT1FAAHIL6STAT3 | |
| SCHEMBL3475420 | 0.90 | HDAC6 (0.67) | HDAC6DGAT1FAAHIL6STAT3 | |
| SCHEMBL11380131 | 0.82 | NPC1 (0.66) | HDAC6NPC1GAARAB9AALDH1A1 | |
| SCHEMBL3475208 | 0.81 | FAAH (0.61) | HDAC6DGAT1FAAHIL6STAT3 | |
| SCHEMBL13436714 | 0.80 | FAAH (0.60) | HDAC6DGAT1FAAHIL6STAT3 | |
| SCHEMBL1675473 | 0.80 | HPSE (0.66) | HDAC6NPC1GAARAB9AALDH1A1 | |
| SCHEMBL3476539 | 0.80 | NPC1 (0.58) | HDAC6DGAT1FAAHIL6STAT3 | |
| SCHEMBL28379205 | 0.79 | HDAC6 (0.78) | HDAC6DGAT1FAAHIL6STAT3 | |
| SCHEMBL3477326 | 0.79 | FAAH (0.62) | HDAC6DGAT1FAAHNPC1GAA | |
| SCHEMBL13436702 | 0.78 | FAAH (0.61) | HDAC6DGAT1FAAHIL6STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039186-A2 | COMPOUNDS USEFUL AS FAAH MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2010-04-08 | — | — | WO | disclosed |
| WO-2010039186-A2 | COMPOUNDS USEFUL AS FAAH MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2010-04-08 | — | — | WO | disclosed |