Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 11/20 | 0.45 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078500 | 0.87 | HRH4 (0.43) | HRH4PARP1PARP2 | |
| SCHEMBL3478547 | 0.85 | KCNH2 (0.36) | SSTR5KCNH2PARP1 | |
| SCHEMBL4087266 | 0.85 | HRH4 (0.44) | HRH4PARP1PARP2 | |
| SCHEMBL4080120 | 0.85 | PARP1 (0.41) | HRH4SSTR5KCNH2PARP1PARP2 | |
| SCHEMBL3864328 | 0.74 | HRH4 (0.43) | HRH4 | |
| SCHEMBL4543952 | 0.73 | HRH4 (0.57) | HRH4SSTR5 | |
| SCHEMBL3477164 | 0.73 | HRH4 (0.55) | HRH4SSTR5KCNH2PTGDR2GRIN2B | |
| SCHEMBL3476897 | 0.72 | HRH4 (0.68) | HRH4SSTR5KCNH2 | |
| SCHEMBL4537534 | 0.72 | HRH4 (0.50) | HRH4SSTR5 | |
| SCHEMBL3477162 | 0.71 | HRH4 (0.61) | HRH4SSTR5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004188-B1 | BENZOIMIDAZOL-2-YL PYRIDINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2010-09-01 | — | — | EP | claimed |