Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 4/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.42 |
| ▸ | MGAM | O43451 | 8/20 | 0.41 |
| ▸ | GAA | P10253 | 8/20 | 0.41 |
| ▸ | SI | P14410 | 8/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 8/20 | 0.41 |
| ▸ | ATR | Q13535 | 4/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.38 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4080120 | 0.90 | PARP1 (0.41) | HRH4PARP1PARP2AURKBAURKA | |
| SCHEMBL4078500 | 0.89 | HRH4 (0.43) | HRH4PARP1PARP2HPSE | |
| SCHEMBL3477289 | 0.85 | HRH4 (0.45) | HRH4PARP1PARP2 | |
| SCHEMBL3478547 | 0.80 | KCNH2 (0.36) | PARP1 | |
| SCHEMBL3864328 | 0.76 | HRH4 (0.43) | HRH4 | |
| SCHEMBL604528 | 0.72 | HRH4 (0.58) | HRH4PARP1PARP2MGAMGAA | |
| SCHEMBL4084534 | 0.72 | HRH4 (0.45) | HRH4PARP1ATR | |
| SCHEMBL3476356 | 0.71 | HRH4 (0.68) | HRH4PARP1PARP2MGAMGAA | |
| SCHEMBL603789 | 0.69 | DRD3 (0.54) | HRH4PARP1MGAMGAASI | |
| SCHEMBL4543952 | 0.68 | HRH4 (0.57) | HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2009532367-A | — | — | 2009-09-10 | — | — | JP | claimed |
| EP-2004188-A4 | BENZOIMIDAZOL-2-YL PYRIDINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-22 | — | — | EP | claimed |
| EP-2004188-A2 | BENZOIMIDAZOL-2-YL PYRIDINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-12-24 | — | — | EP | claimed |
| WO-2007117400-A2 | BENZOIMIDAZOL-2-YL PYRIDINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-18 | — | — | WO | claimed |