Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | CACNB4 | O00305 | 5/20 | 0.47 |
| ▸ | CACNA1A | O00555 | 5/20 | 0.47 |
| ▸ | CACNA1G | O43497 | 5/20 | 0.47 |
| ▸ | CACNG3 | O60359 | 5/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 5/20 | 0.47 |
| ▸ | CACNA1H | O95180 | 5/20 | 0.47 |
| ▸ | CACNB3 | P54284 | 5/20 | 0.47 |
| ▸ | CACNA2D1 | P54289 | 5/20 | 0.47 |
| ▸ | CACNG7 | P62955 | 5/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.47 |
| ▸ | CACNA1D | Q01668 | 5/20 | 0.47 |
| ▸ | CACNB1 | Q02641 | 5/20 | 0.47 |
| ▸ | CACNG1 | Q06432 | 5/20 | 0.47 |
| ▸ | CACNB2 | Q08289 | 5/20 | 0.47 |
| ▸ | CACNA1S | Q13698 | 5/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.47 |
| ▸ | CACNA1E | Q15878 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3470812 | 0.84 | MEN1 (0.57) | MEN1KMT2ACACNB4CACNA1ACACNA1G | |
| SCHEMBL3471468 | 0.83 | RXRA (0.51) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL3472556 | 0.83 | RXRA (0.51) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL3474517 | 0.83 | MALT1 (0.52) | JAK1CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL3473811 | 0.83 | RXRA (0.51) | MEN1KMT2ACACNB4CACNA1ACACNA1G | |
| SCHEMBL3474689 | 0.82 | RXRA (0.49) | MEN1KMT2ARXRANR1H2NR1H3 | |
| SCHEMBL3471359 | 0.82 | RXRA (0.49) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL3473063 | 0.82 | RXRA (0.49) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL3473588 | 0.81 | RXRA (0.52) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL3470736 | 0.81 | RXRA (0.56) | RXRANR1H2NR1H3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331295-A1 | MODULATORS OF LXR | NR1H2, NR1H3, NR1H4 | MEN1 3666/4885KMT2A 2663/4885JAK1 4391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.