Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 20/20 | 0.72 |
| ▸ | TACR2 | P21452 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.72 |
| ▸ | TACR3 | P29371 | 1/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.72 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3476426 | 0.89 | TACR1 (0.72) | TACR1TACR2CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL3475015 | 0.86 | TACR1 (0.54) | TACR1TACR2CYP3A4CYP2C8CYP2D6 | |
| Serlopitant SCHEMBL3183159 | 0.84 | TACR1 (1.00) | TACR1TACR2CYP3A4CYP2C8CYP2D6 | |
| Serlopitant SCHEMBL3184271 | 0.84 | TACR1 (1.00) | TACR1TACR2CYP3A4CYP2C8CYP2D6 | |
| Serlopitant SCHEMBL12646287 | 0.84 | TACR1 (1.00) | TACR1TACR2CYP3A4CYP2C8CYP2D6 | |
| Serlopitant SCHEMBL24067973 | 0.84 | TACR1 (1.00) | TACR1TACR2CYP3A4CYP2C8CYP2D6 | |
| Serlopitant SCHEMBL16280736 | 0.84 | TACR1 (1.00) | TACR1TACR2CYP3A4CYP2C8CYP2D6 | |
| Serlopitant SCHEMBL23883105 | 0.84 | TACR1 (1.00) | TACR1TACR2CYP3A4CYP2C8CYP2D6 | |
| Serlopitant SCHEMBL16280735 | 0.84 | TACR1 (1.00) | TACR1TACR2CYP3A4CYP2C8CYP2D6 | |
| Serlopitant SCHEMBL16333766 | 0.84 | TACR1 (1.00) | TACR1TACR2CYP3A4CYP2C8CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683068-B2 | Hydroisoindoline tachykinin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2010-03-23 | — | — | US | disclosed |
| US-7683068-B2 | Hydroisoindoline tachykinin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2010-03-23 | — | — | US | disclosed |
| US-7683068-B2 | Hydroisoindoline tachykinin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2010-03-23 | — | — | US | disclosed |
| US-20090054462-A1 | Hydroisoindoline tachykinin receptor antagonists | MERCK SHARP & DOHME CORP. | 2009-02-26 | — | — | US | disclosed |
| US-20090054462-A1 | Hydroisoindoline tachykinin receptor antagonists | MERCK SHARP & DOHME CORP. | 2009-02-26 | — | — | US | disclosed |
| US-20090054462-A1 | Hydroisoindoline tachykinin receptor antagonists | MERCK SHARP & DOHME CORP. | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054462-A1 | Hydroisoindoline tachykinin receptor antagonists | TACR1, TACR2, NPSR1 | TACR1 1/4885TACR2 2/4885CYP3A4 3228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.