Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trimethylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimethylammonium SCHEMBL10696615 | 0.91 | CA2 (0.41) | CA2TSHRUSP2CA1TDP1 | |
| Trimethylammonium SCHEMBL140641 | 0.91 | CA2 (0.41) | CA2TSHRUSP2CA1TDP1 | |
| Propane SCHEMBL2200005 | 0.91 | — | — | |
| Trimethylammonium SCHEMBL27903526 | 0.89 | TSHR (0.32) | CA2TSHRUSP2CA1 | |
| Propane SCHEMBL16671226 | 0.88 | CA2 (0.39) | CA2TSHRUSP2CA1TDP1 | |
| Trimethylammonium SCHEMBL29057130 | 0.88 | CA2 (0.39) | CA2TSHRUSP2CA1TDP1 | |
| Trimethylammonium SCHEMBL27625318 | 0.88 | CA2 (0.39) | CA2TSHRUSP2CA1TDP1 | |
| Trimethylammonium SCHEMBL27532388 | 0.88 | CA2 (0.39) | CA2TSHRUSP2CA1TDP1 | |
| Trimethylammonium SCHEMBL27354487 | 0.88 | CA2 (0.39) | CA2TSHRUSP2CA1TDP1 | |
| Trimethylammonium SCHEMBL2479927 | 0.88 | CA2 (0.39) | CA2TSHRUSP2CA1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116617182-A | Preparation and use of cationic polymer lipid nanoparticles | 首都医科大学 | 2023-08-22 | — | — | CN | claimed |
| CN-110157684-A | RFP marks small cell lung cancer cell system and its foundation and application | 浙江省肿瘤医院 | 2019-08-23 | — | — | CN | claimed |
| CN-106177974-A | A kind of preparation carrying antigenic polymers lipid nanospheres and the application as vaccine adjuvant | 王连艳 | 2016-12-07 | — | — | CN | claimed |
| CN-102178652-A | Taxol-loaded nano lipid carrier and preparation method thereof | UNIV SHANDONG | 2011-09-14 | — | — | CN | claimed |
| EP-0276722-A2 | Water soluble cross-linkable polycondensates | BAYER AG (DE) | 1988-08-03 | — | — | EP | claimed |
| CN-112691044-B | Positive charge modified solid lipid nanoparticle and preparation method thereof | 上海家化联合股份有限公司 | 2023-10-17 | — | — | CN | disclosed |
| CN-116617182-A | Preparation and use of cationic polymer lipid nanoparticles | 首都医科大学 | 2023-08-22 | — | — | CN | disclosed |
| CN-112691044-A | Positive charge modified solid lipid nanoparticle and preparation method thereof | 上海家化联合股份有限公司 | 2021-04-23 | — | — | CN | disclosed |
| CN-106177974-B | Preparation of antigen-loaded polymer lipid nanosphere and application of antigen-loaded polymer lipid nanosphere as vaccine adjuvant | 王连艳 | 2020-09-08 | — | — | CN | disclosed |
| CN-111544601-A | Drug delivery particle formulations with targeting moieties | 粒子科学有限公司 | 2020-08-18 | — | — | CN | disclosed |
| CN-110157684-A | RFP marks small cell lung cancer cell system and its foundation and application | 浙江省肿瘤医院 | 2019-08-23 | — | — | CN | disclosed |
| CN-109689110-A | Preparation and application thereof comprising heterocycle ring system | 粒子科学公司 | 2019-04-26 | — | — | CN | disclosed |
| CN-101605530-A | Pharmaceutical preparation and process for its preparation | AMYLIN PHARMACEUTICALS INC (US) | 2009-12-16 | — | — | CN | disclosed |
| EP-2124883-A2 | PHARMACEUTICAL FORMULATIONS AND METHODS FOR MAKING THE SAME | Amylin Pharmaceuticals, Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008073448-A2 | PHARMACEUTICAL FORMULATIONS AND METHODS FOR MAKING THE SAME | AMYLIN PHARMACEUTICALS, INC. (US) | 2008-06-19 | — | — | WO | disclosed |
| CN-101001615-A | Drug delivery product and method | NEXMED HOLDINGS INC (US) | 2007-07-18 | — | — | CN | disclosed |
| EP-0863970-A1 | FABRIC SOFTENING COMPOSITION | UNILEVER PLC (GB) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009403-A1 | FABRIC SOFTENING COMPOSITION | UNILEVER PLC (GB) | 1997-03-13 | — | — | WO | disclosed |
| WO-1995008617-A1 | FABRIC CONDITIONER | UNILEVER PLC (GB) | 1995-03-30 | — | — | WO | disclosed |
| EP-0276722-A2 | Water soluble cross-linkable polycondensates | BAYER AG (DE) | 1988-08-03 | — | — | EP | disclosed |