Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.39 |
| ▸ | KHK | P50053 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 5/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.36 |
| ▸ | CDK2 | P24941 | 4/20 | 0.36 |
| ▸ | IGLV6-57 | P01721 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3480967 | 0.95 | CCR4 (0.43) | CCR4HSP90AA1HSP90AB1KHKEGFR | |
| SCHEMBL8144017 | 0.87 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1KHKROCK2ROCK1 | |
| SCHEMBL3480857 | 0.84 | IGLV6-57 (0.38) | HSP90AA1HSP90AB1EGFRCCNE1CDK2 | |
| SCHEMBL8141002 | 0.79 | PSEN1 (0.41) | HSP90AA1HSP90AB1TSHRMAPTCCNE1 | |
| SCHEMBL8141252 | 0.76 | CCNE1 (0.47) | CYP3A4CYP2D6MAPTCCNE1CDK2 | |
| SCHEMBL3480694 | 0.75 | PSEN1 (0.42) | HSP90AA1HSP90AB1EGFRMAPTCCNE1 | |
| SCHEMBL3017764 | 0.75 | ALK (0.46) | HSP90AA1HSP90AB1EGFRCYP3A4CYP2D6 | |
| SCHEMBL3029387 | 0.75 | ROCK2 (0.50) | HSP90AA1HSP90AB1CCNE1CDK2ROCK2 | |
| SCHEMBL3480665 | 0.74 | CDK2 (0.41) | EGFRMAPTCCNE1CDK2 | |
| SCHEMBL3480972 | 0.74 | CDK2 (0.41) | HSP90AA1HSP90AB1EGFRMAPTCCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8252803-B2 | Piperidine derivatives | MERCK SHARP & DOHME CORP. (US) | 2012-08-28 | — | — | US | disclosed |
| US-8252803-B2 | Piperidine derivatives | MERCK SHARP & DOHME CORP. (US) | 2012-08-28 | — | — | US | disclosed |
| US-8252803-B2 | Piperidine derivatives | MERCK SHARP & DOHME CORP. (US) | 2012-08-28 | — | — | US | disclosed |
| US-20100041680-A1 | PIPERIDINE DERIVATIVES | MERCK SHARP & DOHME CORP. | 2010-02-18 | — | — | US | disclosed |
| US-20100041680-A1 | PIPERIDINE DERIVATIVES | MERCK SHARP & DOHME CORP. | 2010-02-18 | — | — | US | disclosed |
| US-20100041680-A1 | PIPERIDINE DERIVATIVES | MERCK SHARP & DOHME CORP. | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041680-A1 | PIPERIDINE DERIVATIVES | PSEN1, PSEN2, APBA1 | CCR4 3887/4885HSP90AA1 211/4885HSP90AB1 72/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.