Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.51 |
| ▸ | ESRRG | P62508 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5744480 | 0.80 | SIRT6 (0.60) | ALDH1A1MAPTSMN1; SMN2HTTMEN1 | |
| SCHEMBL1126955 | 0.77 | MAPT (0.57) | ALDH1A1MAPTSMN1; SMN2HTTSIRT6 | |
| SCHEMBL374834 | 0.77 | SIRT6 (0.68) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL12952781 | 0.77 | SIRT6 (0.71) | ALDH1A1MAPTSMN1; SMN2L3MBTL1HTT | |
| SCHEMBL7760522 | 0.75 | SIRT6 (0.54) | ALDH1A1MAPTSMN1; SMN2HTTKMT2A | |
| SCHEMBL3455917 | 0.75 | MAPT (1.00) | ALDH1A1MAPTSMN1; SMN2L3MBTL1CYP2C19 | |
| SCHEMBL1126947 | 0.75 | POLB (0.75) | ALDH1A1MAPTSMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL1989595 | 0.74 | SIRT6 (0.64) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6992319 | 0.74 | SIRT6 (0.64) | ALDH1A1MAPTSMN1; SMN2HTTMEN1 | |
| SCHEMBL4252494 | 0.74 | SIRT6 (0.64) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150550-A1 | NOVEL CARBAMOYLOXY ARYL ALKAN ARYLPIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND AND METHOD FOR TREATING PAIN, ANXIETY AND DEPRESSION BY ADMINISTERING THE COMPOUND | SK Holdings Co., Ltd. (KR) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008140197-A1 | NOVEL CARBAMOYLOXY ARYL ALKAN ARYLPIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND AND METHOD FOR TREATING PAIN, ANXIETY AND DEPRESSION BY ADMINISTERING THE COMPOUND | SK HOLDINGS CO., LTD. (KR) | 2008-11-20 | — | — | WO | disclosed |