Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1645241 | 0.79 | SLC6A4 (0.42) | PTGDR2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL31053239 | 0.77 | CYP2C9 (0.51) | MEN1KMT2AALDH1A1MAPTSLC6A4 | |
| SCHEMBL1645250 | 0.76 | SLC6A4 (0.44) | PTGDR2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1644135 | 0.76 | F10 (0.44) | PTGDR2MEN1KMT2ACYP4F2CYP4A11 | |
| SCHEMBL31062426 | 0.76 | PKM (0.42) | KMT2ACYP4F2CYP4A11MAPTPKM | |
| SCHEMBL11965266 | 0.75 | PTGDR2 (0.43) | PTGDR2MEN1KMT2ACYP4F2CYP4A11 | |
| SCHEMBL347144 | 0.74 | ABL1 (0.47) | PTGDR2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1644029 | 0.73 | PTGDR2 (0.41) | PTGDR2MEN1KMT2ACYP4F2CYP4A11 | |
| SCHEMBL1643221 | 0.73 | SLC6A4 (0.47) | PTGDR2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1643111 | 0.72 | PTGDR2 (0.43) | PTGDR2MEN1KMT2ACYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257536-A2 | CYCLIC DIARYL ETHER AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009102893-A2 | CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 receptors | AMIRA PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |