Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | PNLIP | P16233 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | TPO | P07202 | 1/20 | 0.34 |
| ▸ | EPX | P11678 | 1/20 | 0.34 |
| ▸ | LPO | P22079 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.32 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3485032 | 0.90 | PDE7A (0.42) | PDE7AHTR2ASLC6A4PNLIPATM | |
| SCHEMBL3484018 | 0.80 | PDE7A (0.56) | PDE7AMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL2529842 | 0.76 | NPC1 (0.41) | MEN1ALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL3484008 | 0.74 | CYP3A4 (0.34) | PDE7APNLIPMEN1ALDH1A1MAPT | |
| SCHEMBL4318630 | 0.73 | PDE7A (0.63) | PDE7AHTR2ASLC6A4PNLIPCYP1A2 | |
| SCHEMBL3484193 | 0.73 | EGFR (0.49) | PDE7AHTR2ASLC6A4PNLIPATM | |
| SCHEMBL3485235 | 0.72 | CASP1 (0.46) | PDE7AHTR2ASLC6A4PNLIP | |
| SCHEMBL11460671 | 0.72 | HTR2A (0.63) | PDE7AHTR2ASLC6A4PNLIPMPO | |
| SCHEMBL3484631 | 0.71 | PDE7A (0.42) | PDE7AHTR2ASLC6A4PNLIPMPO | |
| SCHEMBL7184491 | 0.70 | PDE7A (0.53) | PDE7AHTR2ASLC6A4PNLIPMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004238-A1 | FUSED HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-01-07 | — | — | US | disclosed |
| EP-2103620-A1 | FUSED HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-09-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004238-A1 | FUSED HETEROCYCLIC COMPOUND | ERBB2, ROS1, FLT3 | PDE7A 4340/4885HTR2A 1970/4885SLC6A4 4245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.