Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 6/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.35 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3485725 | 0.95 | PTGDR2 (0.43) | CNR2PTGDR2KCNQ2KDM4EALDH1A1 | |
| SCHEMBL3485556 | 0.91 | CNR2 (0.52) | CNR2KCNQ2KDM4EALDH1A1HPGD | |
| SCHEMBL8165963 | 0.91 | PTGDR2 (0.41) | CNR2PTGDR2KCNQ2KDM4EALDH1A1 | |
| SCHEMBL3485915 | 0.88 | CYP26A1 (0.46) | CNR2PTGDR2KCNQ2KDM4EALDH1A1 | |
| SCHEMBL3485770 | 0.85 | KCNQ2 (0.42) | CNR2PTGDR2KCNQ2KDM4EALDH1A1 | |
| SCHEMBL3485495 | 0.83 | KCNQ2 (0.47) | CNR2PTGDR2KCNQ2KDM4EALDH1A1 | |
| SCHEMBL3485857 | 0.82 | PPARG (0.50) | CNR2PTGDR2KCNQ2KDM4EALDH1A1 | |
| SCHEMBL3485207 | 0.81 | PTGDR2 (0.39) | CNR2PTGDR2KCNQ2KDM4EALDH1A1 | |
| SCHEMBL3484832 | 0.81 | KCNQ2 (0.48) | PTGDR2KCNQ2KDM4EALDH1A1HPGD | |
| SCHEMBL3485486 | 0.80 | PTGDR2 (0.41) | CNR2PTGDR2SMN1; SMN2F10HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100087446-A1 | 2-SUBSTITUTED INDOLE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MERCK SHARP & DOHME CORP. | 2010-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087446-A1 | 2-SUBSTITUTED INDOLE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | TRPV1, CACNA1S, TRPV2 | CNR2 66/4885PTGDR2 430/4885KCNQ2 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.