Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 16/20 | 0.65 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.61 |
| ▸ | KCNT2 | Q6UVM3 | 1/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 7/20 | 0.52 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13541737 | 0.94 | CACNA1B (0.62) | CACNA1BKCNT1KCNT2NR1I2CACNA1C | |
| SCHEMBL3485740 | 0.94 | CACNA1B (0.61) | CACNA1BKCNT1KCNT2NR1I2CACNA1C | |
| SCHEMBL3484996 | 0.87 | ALDH1A1 (0.61) | CACNA1BNR1I2CYP3A4ALDH1A1POLB | |
| SCHEMBL3486130 | 0.86 | CACNA1B (0.54) | CACNA1BNR1I2CYP3A4ALDH1A1 | |
| SCHEMBL3485776 | 0.86 | CACNA1B (0.54) | CACNA1BNR1I2CYP3A4ALDH1A1 | |
| SCHEMBL3486149 | 0.85 | CACNA1B (0.57) | CACNA1BNR1I2CYP3A4ALDH1A1POLB | |
| SCHEMBL13543316 | 0.84 | CACNA1B (0.51) | CACNA1BKCNT1NR1I2ALDH1A1NPSR1 | |
| SCHEMBL3486066 | 0.83 | CACNA1B (0.56) | CACNA1BNR1I2CYP3A4ALDH1A1POLB | |
| SCHEMBL3485875 | 0.83 | CACNA1B (0.58) | CACNA1BNR1I2CYP3A4 | |
| SCHEMBL3486055 | 0.83 | ALDH1A1 (0.62) | CACNA1BNR1I2CYP3A4ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791264-B2 | Benzenesulfonamide compounds and their use as blockers of calcium channels | PURDUE PHARMA L.P. (US) | 2014-07-29 | — | — | US | claimed |
| US-20100022595-A1 | Benzenesulfonamide Compounds and Their Use as Blockers of Calcium Channels | PURDUE PHARMA L.P. (CT) | 2010-01-28 | — | — | US | claimed |
| WO-2007118853-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS BLOCKERS OF CALCIUM CHANNELS | EURO-CELTIQUE S.A. (LU) | 2007-10-25 | — | — | WO | claimed |
| US-8791264-B2 | Benzenesulfonamide compounds and their use as blockers of calcium channels | PURDUE PHARMA L.P. (US) | 2014-07-29 | — | — | US | disclosed |
| US-20100022595-A1 | Benzenesulfonamide Compounds and Their Use as Blockers of Calcium Channels | PURDUE PHARMA L.P. (CT) | 2010-01-28 | — | — | US | disclosed |
| WO-2007118853-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS BLOCKERS OF CALCIUM CHANNELS | EURO-CELTIQUE S.A. (LU) | 2007-10-25 | — | — | WO | disclosed |
| WO-2007118853-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS BLOCKERS OF CALCIUM CHANNELS | EURO-CELTIQUE S.A. (LU) | 2007-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022595-A1 | Benzenesulfonamide Compounds and Their Use as Blockers of Calcium Channels | CACNA1A, CACNA1E, CACNA1B | CACNA1B 3/4885KCNT1 104/4885KCNT2 113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.