Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 2/20 | 0.51 |
| ▸ | FAAH | O00519 | 5/20 | 0.49 |
| ▸ | TERT | O14746 | 3/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.49 |
| ▸ | PPARG | P37231 | 3/20 | 0.49 |
| ▸ | PPARD | Q03181 | 3/20 | 0.49 |
| ▸ | PPARA | Q07869 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | BLM | P54132 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | FABP4 | P15090 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | GMNN | O75496 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL466724 | 0.84 | CNR2 (0.47) | CNR2FAAHTERTPTPN1PPARG | |
| Bromide SCHEMBL28696429 | 0.79 | FAAH (0.56) | CNR2FAAHTERTPTPN1PPARG | |
| SCHEMBL28942700 | 0.79 | FAAH (0.54) | CNR2FAAHTERTPTPN1PPARG | |
| SCHEMBL8678818 | 0.79 | FAAH (0.54) | CNR2FAAHTERTPTPN1PPARG | |
| SCHEMBL8678813 | 0.79 | FAAH (0.54) | CNR2FAAHTERTPTPN1PPARG | |
| SCHEMBL3660734 | 0.79 | FAAH (0.58) | CNR2FAAHTERTPTPN1PPARG | |
| SCHEMBL3660737 | 0.79 | FAAH (0.58) | CNR2FAAHTERTPTPN1PPARG | |
| SCHEMBL4263808 | 0.79 | FAAH (0.58) | CNR2FAAHTERTPTPN1PPARG | |
| SCHEMBL28370131 | 0.79 | FABP3 (0.61) | FAAHTERTPTPN1PPARGPPARD | |
| SCHEMBL25269311 | 0.78 | FAAH (0.57) | FAAHTERTPTPN1PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100015654-A1 | Negative regulation of NK cell functions by EAT-2, a sap-related adaptor expressed in innate immune cells | Institut De Recherches Cliniques De Montreal/ I.R.C.M. (CA) | 2010-01-21 | — | — | US | disclosed |
| WO-2008148216-A1 | DRAK2 EXPRESSION IS ASSOCIATED WITH DIABETES | CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CA) | 2008-12-11 | — | — | WO | disclosed |
| WO-2006122401-A1 | NEGATIVE REGULATION OF NK CELL FUNCTIONS BY EAT-2, A SAP-RELATED ADAPTOR EXPRESSED IN INNATE IMMUNE CELLS | INSTITUT DE RECHERCHES CLINIQUES DE MONTREAL/I.R.C.M. (CA) | 2006-11-23 | — | — | WO | disclosed |