Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 6/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | AS3MT | Q9HBK9 | 3/20 | 0.35 |
| ▸ | PFKFB2 | O60825 | 3/20 | 0.35 |
| ▸ | PFKFB1 | P16118 | 3/20 | 0.35 |
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | ITK | Q08881 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13435715 | 0.91 | NR1I2 (0.47) | NR1I2CACNA1BSMN1; SMN2GAAAS3MT | |
| SCHEMBL3485598 | 0.85 | NR1I2 (0.49) | NR1I2CACNA1BSMN1; SMN2GAASERPINE1 | |
| SCHEMBL3486182 | 0.85 | NR1I2 (0.52) | NR1I2CACNA1BSMN1; SMN2GAASERPINE1 | |
| SCHEMBL13401210 | 0.85 | NR1I2 (0.48) | NR1I2CACNA1BSMN1; SMN2GAASERPINE1 | |
| SCHEMBL3486030 | 0.84 | NR1I2 (0.47) | NR1I2CACNA1BSMN1; SMN2GAASERPINE1 | |
| SCHEMBL3485683 | 0.79 | NR1I2 (0.74) | NR1I2CACNA1BSMN1; SMN2GAASERPINE1 | |
| SCHEMBL13435719 | 0.76 | NR1I2 (0.48) | NR1I2CACNA1BSMN1; SMN2GAAHPGD | |
| SCHEMBL13435657 | 0.75 | NR1I2 (0.51) | NR1I2CACNA1BSMN1; SMN2GAAHPGD | |
| SCHEMBL8144031 | 0.75 | NR1I2 (0.67) | NR1I2CACNA1BSMN1; SMN2GAANPC1 | |
| SCHEMBL13435512 | 0.75 | NR1I2 (0.46) | NR1I2CACNA1BSMN1; SMN2GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100087446-A1 | 2-SUBSTITUTED INDOLE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MERCK SHARP & DOHME CORP. | 2010-04-08 | — | — | US | disclosed |
| US-20100087446-A1 | 2-SUBSTITUTED INDOLE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MERCK SHARP & DOHME CORP. | 2010-04-08 | — | — | US | disclosed |
| US-20100087446-A1 | 2-SUBSTITUTED INDOLE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MERCK SHARP & DOHME CORP. | 2010-04-08 | — | — | US | disclosed |
| WO-2008133867-A1 | 2-SUBSTITUTED INDOLE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MERCK & CO., INC. (US) | 2008-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087446-A1 | 2-SUBSTITUTED INDOLE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | TRPV1, CACNA1S, TRPV2 | NR1I2 1761/4885CACNA1B 13/4885SMN1; SMN2 650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.