Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 5/20 | 0.51 |
| ▸ | FYN | P06241 | 5/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.46 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13498808 | 0.96 | MAP3K5 (0.55) | MAP3K5FYNKDRBTKPOLB | |
| Trifluoroacetic Acid SCHEMBL3486117 | 0.89 | MAP3K5 (0.53) | MAP3K5KDRRIPK1CSNK1DCSNK1E | |
| SCHEMBL13498805 | 0.86 | MAP3K5 (0.56) | MAP3K5KDRRIPK1CSNK1DCSNK1E | |
| Trifluoroacetic Acid SCHEMBL3486400 | 0.85 | RIPK1 (0.51) | MAP3K5KDRRIPK1 | |
| SCHEMBL3486280 | 0.83 | MAP3K5 (0.67) | MAP3K5CSNK1DCSNK1EPOLB | |
| SCHEMBL13498811 | 0.82 | RIPK1 (0.53) | MAP3K5KDRRIPK1 | |
| Trifluoroacetic Acid SCHEMBL3486311 | 0.82 | MAP3K5 (0.52) | MAP3K5CSNK1DCSNK1E | |
| Trifluoroacetic Acid SCHEMBL3486304 | 0.81 | MAP3K5 (0.52) | MAP3K5CSNK1DCSNK1E | |
| Trifluoroacetic Acid SCHEMBL3486616 | 0.80 | MAP3K5 (0.52) | MAP3K5CSNK1DCSNK1E | |
| Trifluoroacetic Acid SCHEMBL3487005 | 0.80 | MAP3K5 (0.52) | MAP3K5CSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029619-A1 | FUSED HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMTED (JP) | 2010-02-04 | — | — | US | disclosed |
| EP-2058309-A1 | FUSED HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-05-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029619-A1 | FUSED HETEROCYCLIC COMPOUND | IRAK1, IL1R1, IRAK2 | MAP3K5 42/4885FYN 420/4885PIK3CA 2525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.