Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 6/20 | 0.52 |
| ▸ | NOTCH1 | P46531 | 3/20 | 0.47 |
| ▸ | RBPJ | Q06330 | 2/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.46 |
| ▸ | CCKAR | P32238 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | NOTCH3 | Q9UM47 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3487371 | 1.00 | CCKBR (0.52) | CCKBRNOTCH1RBPJPSEN1PSEN2 | |
| SCHEMBL14371751 | 0.94 | CCKBR (0.54) | CCKBRNOTCH1RBPJPSEN1PSEN2 | |
| SCHEMBL3487753 | 0.91 | CCKBR (0.50) | CCKBRNOTCH1RBPJPSEN1PSEN2 | |
| SCHEMBL13434960 | 0.90 | CCKBR (0.46) | CCKBRNOTCH1RBPJPSEN1PSEN2 | |
| SCHEMBL3486334 | 0.88 | CCKBR (0.63) | CCKBRNOTCH1RBPJPSEN1PSEN2 | |
| SCHEMBL13501672 | 0.88 | CCKBR (0.63) | CCKBRNOTCH1RBPJPSEN1PSEN2 | |
| SCHEMBL3486674 | 0.88 | CCKBR (0.63) | CCKBRNOTCH1RBPJPSEN1PSEN2 | |
| SCHEMBL3488147 | 0.88 | NOTCH1 (0.47) | CCKBRNOTCH1RBPJPSEN1PSEN2 | |
| SCHEMBL3486223 | 0.87 | NOTCH1 (0.51) | CCKBRNOTCH1RBPJPSEN1PSEN2 | |
| SCHEMBL3486229 | 0.87 | NOTCH1 (0.51) | CCKBRNOTCH1RBPJPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7498324-B2 | Substituted lactams as inhibitors of Aβ protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2009-03-03 | — | — | US | claimed |
| US-20080221087-A1 | Substituted lactams as inhibitors of abeta protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2008-09-11 | — | — | US | claimed |
| US-20070173491-A1 | Substituted lactams as inhibitors of Abeta protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2007-07-26 | — | — | US | claimed |
| US-20050234039-A1 | Prevent forming deposits of amyloid protein on nervous systems; Alzheimer's disease; Down syndrome | HAN QI | 2005-10-20 | — | — | US | claimed |
| US-20040138201-A1 | Substituted lactams as inhibitors of Abeta protein production | HAN QI (US) | 2004-07-15 | — | — | US | claimed |
| US-6632812-B2 | Alzheimer's disease; Down syndrom | DUPONT PHARMACEUTICALS COMPANY | 2003-10-14 | — | — | US | claimed |
| US-20020025955-A1 | Substituted lactams as inhibitors of A beta protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-02-28 | — | — | US | claimed |
| US-20100069373-A1 | SUBSTITUTED LACTAMS AS INHIBITORS OF A BETA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2010-03-18 | — | — | US | disclosed |
| US-20100056501-A1 | SUBSTITUTED LACTAMS AS INHIBITORS OF ABETA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2010-03-04 | — | — | US | disclosed |
| US-20100048541-A1 | SUBSTITUTED LACTAMS AS INHIBITORS OF ABETA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2010-02-25 | — | — | US | disclosed |
| US-7655647-B2 | Substituted lactams as inhibitors of Aβ protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2010-02-02 | — | — | US | disclosed |
| US-20100009966-A1 | SUBSTITUTED LACTAMS AS INHIBITORS OF ABETA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2010-01-14 | — | — | US | disclosed |
| US-20090170831-A1 | SUBSTITUTED LACTAMS AS INHIBITORS OF ABETA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2009-07-02 | — | — | US | disclosed |
| US-20070173491-A1 | Substituted lactams as inhibitors of Abeta protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2007-07-26 | — | — | US | disclosed |
| US-20060211679-A1 | Substituted lactams as inhibitors of Abeta protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2006-09-21 | — | — | US | disclosed |
| US-20050234039-A1 | Prevent forming deposits of amyloid protein on nervous systems; Alzheimer's disease; Down syndrome | HAN QI | 2005-10-20 | — | — | US | disclosed |
| US-6900199-B2 | Substituted lactams as inhibitors of Aβ protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-05-31 | — | — | US | disclosed |
| US-20040138201-A1 | Substituted lactams as inhibitors of Abeta protein production | HAN QI (US) | 2004-07-15 | — | — | US | disclosed |
| US-6632812-B2 | Alzheimer's disease; Down syndrom | DUPONT PHARMACEUTICALS COMPANY | 2003-10-14 | — | — | US | disclosed |
| US-20020025955-A1 | Substituted lactams as inhibitors of A beta protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221087-A1 | Substituted lactams as inhibitors of abeta protein production | BACE1, APP, APH1A | CCKBR 2802/4885NOTCH1 125/4885RBPJ 1928/4885 |
| US-20020025955-A1 | Substituted lactams as inhibitors of A beta protein production | BACE1, APP, APH1A | CCKBR 3093/4885NOTCH1 281/4885RBPJ 2526/4885 |
| US-20100009966-A1 | SUBSTITUTED LACTAMS AS INHIBITORS OF ABETA PROTEIN PRODUCTION | BACE1, APP, APH1A | CCKBR 2802/4885NOTCH1 125/4885RBPJ 1928/4885 |
| US-20100048541-A1 | SUBSTITUTED LACTAMS AS INHIBITORS OF ABETA PROTEIN PRODUCTION | BACE1, APP, APH1A | CCKBR 2802/4885NOTCH1 125/4885RBPJ 1928/4885 |
| US-20090170831-A1 | SUBSTITUTED LACTAMS AS INHIBITORS OF ABETA PROTEIN PRODUCTION | BACE1, APP, APH1A | CCKBR 2765/4885NOTCH1 98/4885RBPJ 1845/4885 |
| US-20040138201-A1 | Substituted lactams as inhibitors of Abeta protein production | BACE1, APP, APH1A | CCKBR 2797/4885NOTCH1 158/4885RBPJ 2163/4885 |
| US-20060211679-A1 | Substituted lactams as inhibitors of Abeta protein production | BACE1, APP, APH1A | CCKBR 2802/4885NOTCH1 125/4885RBPJ 1928/4885 |
| US-20070173491-A1 | Substituted lactams as inhibitors of Abeta protein production | BACE1, APP, APH1A | CCKBR 2802/4885NOTCH1 125/4885RBPJ 1928/4885 |
| US-20100069373-A1 | SUBSTITUTED LACTAMS AS INHIBITORS OF A BETA PROTEIN PRODUCTION | BACE1, APP, BACE2 | CCKBR 3027/4885NOTCH1 167/4885RBPJ 2285/4885 |
| US-20100056501-A1 | SUBSTITUTED LACTAMS AS INHIBITORS OF ABETA PROTEIN PRODUCTION | BACE1, APP, APH1A | CCKBR 2802/4885NOTCH1 125/4885RBPJ 1928/4885 |
| US-20050234039-A1 | Prevent forming deposits of amyloid protein on nervous systems; Alzheimer's disease; Down syndrome | APP, BACE1, PSEN1 | CCKBR 3583/4885NOTCH1 147/4885RBPJ 2603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.