Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 2/20 | 0.38 |
| ▸ | GABRB1 known ✓ | P18505 | 2/20 | 0.38 |
| ▸ | GABRG2 known ✓ | P18507 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 6/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.60 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.60 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 2/20 | 0.38 |
| ▸ | GABRD | O14764 | 2/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.38 |
| ▸ | GABRE | P78334 | 2/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL4931958 | 1.00 | TSHR (0.67) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Cadaverine Tartrate SCHEMBL348912 | 1.00 | TSHR (0.67) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Cadaverine Tartrate SCHEMBL10454999 | 0.97 | TSHR (0.62) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Cadaverine Tartrate SCHEMBL9497188 | 0.94 | TSHR (0.59) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Cadaverine Tartrate SCHEMBL630785 | 0.86 | TSHR (0.91) | TSHRTP53ALDH1A1CYP2C9PDE4A | |
| Cadaverine Tartrate SCHEMBL1062721 | 0.82 | TSHR (1.00) | TSHRTP53ALDH1A1CYP2C9PDE4A | |
| Cadaverine Tartrate SCHEMBL1431070 | 0.82 | TSHR (1.00) | TSHRTP53ALDH1A1CYP2C9PDE4A | |
| Tartaric Acid SCHEMBL5762 | 0.82 | TSHR (1.00) | TSHRTP53ALDH1A1CYP2C9PDE4A | |
| Cadaverine Tartrate SCHEMBL116846 | 0.82 | TSHR (1.00) | TSHRTP53ALDH1A1CYP2C9PDE4A | |
| Cadaverine Tartrate SCHEMBL22768 | 0.82 | TSHR (1.00) | TSHRTP53ALDH1A1CYP2C9PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 193 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114507227-B | Benzisothiazole compound, preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2024-06-21 | — | — | CN | claimed |
| CN-114591318-B | Pyrazolo heterocyclic compound, preparation method thereof, pharmaceutical composition and application | 中国医学科学院药物研究所 | 2024-06-21 | — | — | CN | claimed |
| CN-115466251-B | Condensed heterocyclic compound, preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2024-06-21 | — | — | CN | claimed |
| CN-114507243-B | Isothiazolo heterocyclic compounds, preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2024-05-14 | — | — | CN | claimed |
| CN-115504973-B | Benzisoxazole compound, preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2024-05-14 | — | — | CN | claimed |
| CN-111943906-B | Amidine derivatives, preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2023-12-15 | — | — | CN | claimed |
| CN-116924976-A | Diaryl heterocyclic amine compound, preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2023-10-24 | — | — | CN | claimed |
| CN-115504973-A | Benzisoxazole compound, preparation method thereof, pharmaceutical composition and application | 中国医学科学院药物研究所 | 2022-12-23 | — | — | CN | claimed |
| CN-115466251-A | Fused heterocyclic compound, preparation method thereof, pharmaceutical composition and application | 中国医学科学院药物研究所 | 2022-12-13 | — | — | CN | claimed |
| CN-115073442-A | Disulfide bond-containing compound, preparation method thereof, pharmaceutical composition and application | 中国医学科学院药物研究所 | 2022-09-20 | — | — | CN | claimed |
| CN-108929280-A | Pyrazine derivative and its preparation method and pharmaceutical composition and purposes | 中国医学科学院药物研究所 | 2018-12-04 | — | — | CN | claimed |
| US-20180140701-A1 | Stable Aqueous Formulations of Adalimumab | Coherus Biosciences, Inc. | 2018-05-24 | — | — | US | claimed |
| WO-2018020512-A1 | SLOW RELEASE COMPOSITION OF ACTIVE INGREDIENTS | PARACHUR VIVEK ANAND (IN) | 2018-02-01 | — | — | WO | claimed |
| US-9861695-B2 | Stable aqueous formulations of adalimumab | Coherus Biosciences, Inc. (US) | 2018-01-09 | — | — | US | claimed |
| CN-107434789-A | BTA analog derivative and its preparation method and pharmaceutical composition and purposes | 中国医学科学院药物研究所 | 2017-12-05 | — | — | CN | claimed |
| CN-107417666-A | Bromo benzyl oxide derivative and its preparation method and pharmaceutical composition and purposes | 中国医学科学院药物研究所 | 2017-12-01 | — | — | CN | claimed |
| CN-107417572-A | Benzyl phenylate analog derivative and its preparation method and pharmaceutical composition and purposes | 中国医学科学院药物研究所 | 2017-12-01 | — | — | CN | claimed |
| CN-107417564-A | Phenylate analog derivative and its preparation method and pharmaceutical composition and purposes | 中国医学科学院药物研究所 | 2017-12-01 | — | — | CN | claimed |
| CN-102786517-B | The pyrimidine thiazole amines derivative of GK and PPAR double excitation activity | 中国医学科学院药物研究所 | 2017-06-06 | — | — | CN | claimed |
| US-20170072054-A1 | Stable Aqueous Formulations of Adalimumab | Coherus Biosciences, Inc. | 2017-03-16 | — | — | US | claimed |