Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 2/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.31 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12059552 | 0.84 | IDO1 (0.38) | IDO1PYCR1CCR2ADRA2AADRA2B | |
| SCHEMBL13461942 | 0.82 | IDO1 (0.37) | IDO1PYCR1CCR2NOTUMADRA2A | |
| SCHEMBL13461854 | 0.82 | IDO1 (0.37) | IDO1PYCR1CCR2NOTUMADRA2A | |
| SCHEMBL3491800 | 0.82 | KIF11 (0.44) | IDO1PYCR1CCR2ARPTPN7 | |
| SCHEMBL17295109 | 0.79 | IDO1 (0.35) | IDO1PYCR1CCR2ADRA2AADRA2B | |
| SCHEMBL2092880 | 0.78 | IDO1 (0.44) | IDO1PYCR1CCR2ADRA2AADRA2B | |
| SCHEMBL932921 | 0.77 | IDO1 (0.62) | IDO1PYCR1GPR84NOTUM | |
| SCHEMBL29560777 | 0.77 | PTPN7 (0.45) | IDO1ARCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL1717487 | 0.77 | PTPN7 (0.45) | IDO1ARCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7786392 | 0.77 | TTR (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492378-B2 | GSK-3β inhibitor | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-07-23 | — | — | US | disclosed |
| US-20100069381-A1 | GSK-3BETAINHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069381-A1 | GSK-3BETAINHIBITOR | GSK3B, GSK3A, GSKIP | IDO1 1290/4885PYCR1 2780/4885CCR2 3853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.