Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 6/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3490479 | 0.81 | KDM4E (0.45) | GSK3BAURKAGSK3ANPC1RAB9A | |
| SCHEMBL3491112 | 0.76 | GSK3B (0.46) | MAPK10GSK3BAURKAGSK3ANPC1 | |
| SCHEMBL3493182 | 0.76 | KMT2A (0.52) | MEN1KMT2AKDRNPC1RAB9A | |
| SCHEMBL3491183 | 0.76 | GSK3B (0.52) | GSK3BAURKAGSK3APIK3C3NPC1 | |
| SCHEMBL4079482 | 0.76 | TSHR (0.50) | GSK3BAURKAGSK3AMEN1KMT2A | |
| SCHEMBL3493232 | 0.76 | MAPK10 (0.47) | MAPK10MEN1KMT2APIK3C3NPC1 | |
| SCHEMBL3493004 | 0.75 | THRB (0.53) | AURKANPC1RAB9A | |
| SCHEMBL3491927 | 0.75 | MAPK10 (0.42) | MAPK10GSK3BMAPK8RAB9ADYRK1A | |
| SCHEMBL3491649 | 0.75 | GSK3B (0.48) | MAPK10GSK3B | |
| SCHEMBL3493576 | 0.75 | MAPK1 (0.53) | GSK3BAURKAGSK3AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492378-B2 | GSK-3β inhibitor | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-07-23 | — | — | US | disclosed |
| US-20100069381-A1 | GSK-3BETAINHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069381-A1 | GSK-3BETAINHIBITOR | GSK3B, GSK3A, GSKIP | MAPK10 671/4885TYK2 1004/4885GSK3B 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.