Sugi Predict

Sugi Predict / Compounds / SCHEMBL3496130

SCHEMBL3496130

SCHEMBL3496130

COCCN1C(=O)COc2cc(-c3ccccc3Nc3ncc(C#N)c(NC4CC(C)(C)NC(C)(C)C4)n3)ccc21

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CSNK2A2 P19784 1/20 0.35
▸ CSNK2A1 P68400 1/20 0.35
▸ PKMYT1 Q99640 2/20 0.35
▸ LRRK2 Q5S007 8/20 0.34
▸ EGFR P00533 1/20 0.34
▸ INSR P06213 3/20 0.34
▸ ALK Q9UM73 3/20 0.34
▸ MERTK Q12866 1/20 0.33
▸ SLC2A1 P11166 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ USP2 O75604 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ CYP1A2 P05177 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33
▸ CYP2D6 P10635 1/20 0.33
▸ TSHR P16473 1/20 0.33
▸ CASP1 P29466 1/20 0.33
▸ CASP7 P55210 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ CLK4 Q9HAZ1 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3495366 0.93 CSNK2A2 (0.35) CSNK2A2CSNK2A1PKMYT1LRRK2EGFR
SCHEMBL3495846 0.90 INSR (0.36) CSNK2A2CSNK2A1LRRK2EGFRINSR
SCHEMBL3494871 0.88 SYK (0.45) —
SCHEMBL3494264 0.84 LRRK2 (0.36) CSNK2A2CSNK2A1PKMYT1LRRK2EGFR
SCHEMBL3495502 0.83 LRRK2 (0.35) CSNK2A2CSNK2A1PKMYT1LRRK2EGFR
SCHEMBL3496148 0.83 PRKCQ (0.41) CSNK2A2CSNK2A1LRRK2EGFRINSR
SCHEMBL3496133 0.82 CYP1A2 (0.42) INSRMERTKMEN1USP2ALDH1A1
SCHEMBL3493831 0.81 SYK (0.45) —
SCHEMBL3496532 0.80 SYK (0.41) CSNK2A2CSNK2A1PKMYT1LRRK2ALK
SCHEMBL3497184 0.79 SYK (0.45) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100130486-A1 CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS RIGEL PHARMACEUTICALS, INC. 2010-05-27 — — US claimed
EP-2183225-A1 CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS Rigel Pharmaceuticals, Inc. (US) 2010-05-12 — — EP claimed
WO-2009012421-A1 CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS RIGEL PHARMACEUTICALS, INC. (US) 2009-01-22 — — WO claimed
US-8993585-B2 Cyclic amine substituted pyrimidinediamines as PKC inhibitors RIGEL PHARMACEUTICALS, INC. (US) 2015-03-31 — — US disclosed
US-20100130486-A1 CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS RIGEL PHARMACEUTICALS, INC. 2010-05-27 — — US disclosed
EP-2183225-A1 CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS Rigel Pharmaceuticals, Inc. (US) 2010-05-12 — — EP disclosed
WO-2009012421-A1 CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS RIGEL PHARMACEUTICALS, INC. (US) 2009-01-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100130486-A1 CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS PRKCH, PKD2, PRKCQ CSNK2A2 643/4885CSNK2A1 617/4885PKMYT1 155/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.