Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.56 |
| ▸ | DRD4 | P21917 | 3/20 | 0.56 |
| ▸ | DRD3 | P35462 | 3/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3188150 | 0.91 | DRD2 (0.56) | DRD2DRD4DRD3CYP11B1CYP11B2 | |
| SCHEMBL3495975 | 0.90 | DRD2 (0.55) | DRD2DRD4DRD3CYP11B1CYP11B2 | |
| SCHEMBL3496245 | 0.90 | DRD2 (0.55) | DRD2DRD4DRD3CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL3495879 | 0.90 | DRD2 (0.55) | DRD2DRD4DRD3CYP11B1CYP11B2 | |
| SCHEMBL3496078 | 0.89 | DRD2 (0.54) | DRD2DRD4DRD3CYP11B1CYP11B2 | |
| SCHEMBL3496620 | 0.88 | DRD2 (0.51) | DRD2DRD4DRD3CYP11B1CYP11B2 | |
| SCHEMBL3498104 | 0.85 | DRD2 (0.52) | DRD2DRD4DRD3HTTSMN1; SMN2 | |
| SCHEMBL3496134 | 0.83 | CYP11B1 (0.48) | DRD2DRD4DRD3CYP11B1CYP11B2 | |
| SCHEMBL3499222 | 0.83 | CYP11B1 (0.48) | DRD2DRD4DRD3CYP11B1CYP11B2 | |
| SCHEMBL3496274 | 0.83 | CYP11B1 (0.46) | DRD2DRD4DRD3CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803825-B2 | Aminoalkylazole derivatives as histamine-3 antagonists | WYETH LLC (US) | 2010-09-28 | — | — | US | claimed |