⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7590188 | 1.00 | — | — | |
| SCHEMBL6281917 | 0.79 | — | — | |
| SCHEMBL65155 | 0.78 | — | — | |
| SCHEMBL5819277 | 0.78 | THRB (0.39) | — | |
| SCHEMBL1639142 | 0.78 | — | — | |
| SCHEMBL7156637 | 0.78 | THRB (0.39) | — | |
| SCHEMBL20472787 | 0.78 | THRB (0.39) | — | |
| SCHEMBL31990 | 0.78 | — | — | |
| SCHEMBL1638758 | 0.78 | — | — | |
| SCHEMBL300449 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 112 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613737-B1 | NOVEL INHIBITOR OF CYCLIN-DEPENDENT KINASE CDK9 | GENFLEET THERAPEUTICS SHANGHAI INC (CN) | 2021-12-29 | — | — | EP | claimed |
| US-10952999-B2 | Inhibitor of cyclin-dependent kinase CDK9 | GENFLEET THERAPEUTICS (SHANGHAI) INC. (CN) | 2021-03-23 | — | — | US | claimed |
| US-20200078343-A1 | NOVEL INHIBITOR OF CYCLIN-DEPENDENT KINASE CDK9 | Shanghai Jiongshuo Pharmaceutical Technology Co., Ltd. (CN) | 2020-03-12 | — | — | US | claimed |
| EP-3613737-A1 | NOVEL INHIBITOR OF CYCLIN-DEPENDENT KINASE CDK9 | Genfleet Therapeutics (Shanghai) Inc. (CN) | 2020-02-26 | — | — | EP | claimed |
| CN-101845091-A | Metastin derivative and use thereof | TAKEDA PHARMACEUTICAL | 2010-09-29 | — | — | CN | claimed |
| US-20070179161-A1 | Pyrazolopyrimidine compounds and their use in medicine | VERNALIS (CAMBRIDGE) LIMITED. (GB) | 2007-08-02 | — | — | US | claimed |
| EP-1608652-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE IN MEDICINE | Vernalis (Cambridge) Limited (GB) | 2005-12-28 | — | — | EP | claimed |
| WO-2004087707-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE IN MEDICINE | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2004-10-14 | — | — | WO | claimed |
| US-5977102-A | INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES OR EPIDERMAL GROWTH FACTOR; ANTITUMOR,-CARCINOGENIC, -METASTASIS,-PROLIFERATION AGENTS AND -INFLAMMATORY AGENTS; PSORIASIS; ANGIOGENESIS INHIBITORS; IMMUNOLOGY; | DR. KARL THOMAE GMBH (DE) | 1999-11-02 | — | — | US | claimed |
| CN-1212696-A | Pyrimido [5, 4-d ] pyrimidines, medicaments containing these compounds, their use and processes for their preparation | THOMAE GMBH DR K (DE) | 1999-03-31 | — | — | CN | claimed |
| EP-0885227-A1 | PYRIMIDO 5,4-d]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1998-12-23 | — | — | EP | claimed |
| WO-1997032882-A1 | PYRIMIDO[5,4-d]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | claimed |
| CN-114106666-B | Coating composition | 中国涂料株式会社 | 2024-03-08 | — | — | CN | disclosed |
| CN-116157211-B | Low VOC coating composition, coating film and substrate having coating film, and methods for producing the same | 中国涂料株式会社 | 2024-03-08 | — | — | CN | disclosed |
| CN-114058237-B | Corrosion resistant coating composition | 中国涂料株式会社 | 2023-12-26 | — | — | CN | disclosed |
| CN-116981743-A | Corrosion protection composition 1 and corrosion protection coating composition | 中国涂料株式会社 | 2023-10-31 | — | — | CN | disclosed |
| WO-1994013313-A1 | 6-POSITION MODIFIED DECAPEPTIDE LHRH ANTAGONISTS | ABBOTT LABORATORIES (US) | 1994-06-23 | — | — | WO | disclosed |
| US-5215967-A | AMINOACID DERIVATIVES INHIBITING RENIN | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-06-01 | — | — | US | disclosed |
| EP-0371390-A2 | Amino acid derivatives | MERCK PATENT GmbH (DE) | 1990-06-06 | — | — | EP | disclosed |
| US-4611054-A | GLUCAGON, GROWTH HORMONE AND INSULIN RELEASE INHIBITORS | MERCK & CO., INC. (US) | 1986-09-09 | — | — | US | disclosed |