Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 15/20 | 0.61 |
| ▸ | BRD4 | O60885 | 2/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | BTK | Q06187 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3496536 | 0.85 | AURKA (0.58) | AURKABRD4EGFRBTKAURKB | |
| SCHEMBL3495530 | 0.85 | PRKCQ (0.51) | AURKABRD4EGFRBTKAURKB | |
| SCHEMBL3494810 | 0.84 | PRKCQ (0.50) | AURKABRD4EGFRBTKAURKB | |
| SCHEMBL3497350 | 0.83 | AURKA (0.58) | AURKAEGFRBTKAURKBPRKCQ | |
| SCHEMBL14607329 | 0.83 | AURKA (0.67) | AURKABRD4EGFRBTKAURKB | |
| SCHEMBL3494982 | 0.82 | SYK (0.56) | AURKAEGFRBTKAURKBPRKCQ | |
| SCHEMBL3493781 | 0.81 | PRKCQ (0.56) | AURKABRD4EGFRBTKAURKB | |
| SCHEMBL3495899 | 0.80 | PRKCQ (0.59) | AURKAEGFRBTKAURKBPRKCQ | |
| SCHEMBL3493447 | 0.79 | CDK2 (0.55) | AURKAAURKBPRKCQ | |
| SCHEMBL3496493 | 0.79 | SYK (0.62) | AURKAEGFRBTKAURKBPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130486-A1 | CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS | RIGEL PHARMACEUTICALS, INC. | 2010-05-27 | — | — | US | claimed |
| US-8993585-B2 | Cyclic amine substituted pyrimidinediamines as PKC inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2015-03-31 | — | — | US | disclosed |
| US-20100130486-A1 | CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS | RIGEL PHARMACEUTICALS, INC. | 2010-05-27 | — | — | US | disclosed |
| EP-2183225-A1 | CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009012421-A1 | CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130486-A1 | CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS | PRKCH, PKD2, PRKCQ | AURKA 495/4885BRD4 1173/4885EGFR 1181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.