Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | CACNB4 | O00305 | 4/20 | 0.43 |
| ▸ | CACNA1A | O00555 | 4/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.43 |
| ▸ | CACNG3 | O60359 | 4/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 4/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.43 |
| ▸ | CACNB3 | P54284 | 4/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.43 |
| ▸ | CACNG7 | P62955 | 4/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.43 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.43 |
| ▸ | CACNB1 | Q02641 | 4/20 | 0.43 |
| ▸ | CACNG1 | Q06432 | 4/20 | 0.43 |
| ▸ | CACNB2 | Q08289 | 4/20 | 0.43 |
| ▸ | CACNA1S | Q13698 | 4/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3497726 | 0.99 | HRH3 (0.48) | HRH3DRD2DRD4DRD3CACNB4 | |
| SCHEMBL3497062 | 0.92 | HRH3 (0.49) | HRH3DRD2DRD4DRD3CACNB4 | |
| SCHEMBL3497306 | 0.91 | HRH3 (0.48) | HRH3DRD2DRD4DRD3CACNB4 | |
| SCHEMBL3497815 | 0.88 | HRH3 (0.54) | HRH3DRD2DRD4DRD3BRD4 | |
| SCHEMBL3497317 | 0.87 | HRH3 (0.52) | HRH3DRD2DRD4DRD3BRD4 | |
| SCHEMBL3495975 | 0.86 | DRD2 (0.55) | HRH3DRD2DRD4DRD3SMN1; SMN2 | |
| SCHEMBL3496245 | 0.86 | DRD2 (0.55) | HRH3DRD2DRD4DRD3SMN1; SMN2 | |
| SCHEMBL3188150 | 0.85 | DRD2 (0.56) | HRH3DRD2DRD4DRD3SMN1; SMN2 | |
| SCHEMBL3497690 | 0.84 | BRD4 (0.41) | HRH3DRD2DRD4DRD3BRD4 | |
| Hydrochloric Acid SCHEMBL3495879 | 0.84 | DRD2 (0.55) | HRH3DRD2DRD4DRD3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803825-B2 | Aminoalkylazole derivatives as histamine-3 antagonists | WYETH LLC (US) | 2010-09-28 | — | — | US | claimed |
| EP-2170875-A1 | AMINOALKYLAZOLE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | Wyeth LLC (US) | 2010-04-07 | — | — | EP | claimed |
| WO-2009012252-A1 | AMINOALKYLAZOLE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2009-01-22 | — | — | WO | claimed |
| US-20090023707-A1 | AMINOALKYLAZOLE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2009-01-22 | — | — | US | claimed |
| US-7803825-B2 | Aminoalkylazole derivatives as histamine-3 antagonists | WYETH LLC (US) | 2010-09-28 | — | — | US | disclosed |
| EP-2170875-A1 | AMINOALKYLAZOLE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | Wyeth LLC (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009012252-A1 | AMINOALKYLAZOLE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2009-01-22 | — | — | WO | disclosed |
| US-20090023707-A1 | AMINOALKYLAZOLE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023707-A1 | AMINOALKYLAZOLE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | HRH4, HRH3, HRH2 | HRH3 2/4885DRD2 419/4885DRD4 1020/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.