Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 12/20 | 0.44 |
| ▸ | BTK | Q06187 | 6/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 7/20 | 0.43 |
| ▸ | SELP | P16109 | 4/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
| ▸ | IKBKB | O14920 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | PAK4 | O96013 | 2/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | INSR | P06213 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3495585 | 0.87 | PRKCQ (0.57) | PRKCQEGFRBTKAURKAITK | |
| SCHEMBL3493105 | 0.84 | EGFR (0.45) | PRKCQEGFRBTKTYRO3SELP | |
| SCHEMBL3493106 | 0.84 | EGFR (0.45) | PRKCQEGFRBTKTYRO3SELP | |
| SCHEMBL3496512 | 0.84 | PRKCQ (0.59) | PRKCQEGFRBTKTYRO3SELP | |
| SCHEMBL3495646 | 0.84 | PRKCQ (0.46) | PRKCQEGFRBTKTYRO3SELP | |
| SCHEMBL3495573 | 0.83 | EGFR (0.50) | PRKCQEGFRBTKTYRO3AURKA | |
| SCHEMBL3496614 | 0.82 | PRKCQ (0.47) | PRKCQEGFRBTKTYRO3SELP | |
| SCHEMBL3495136 | 0.80 | PRKCQ (0.48) | PRKCQEGFRBTKTYRO3SELP | |
| SCHEMBL3495681 | 0.80 | ULK1 (0.51) | PRKCQEGFRBTKAURKAJAK3 | |
| SCHEMBL3495479 | 0.78 | PRKCQ (0.53) | PRKCQEGFRBTKTYRO3SELP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993585-B2 | Cyclic amine substituted pyrimidinediamines as PKC inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2015-03-31 | — | — | US | disclosed |
| US-20100130486-A1 | CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS | RIGEL PHARMACEUTICALS, INC. | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130486-A1 | CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS | PRKCH, PKD2, PRKCQ | PRKCQ 3/4885EGFR 1181/4885BTK 97/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.