SCHEMBL3499464

SCHEMBL3499464

CCCCCC(N)CC[Si](OC)(OC)OC

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.43
S1PR2 O95136 5/20 0.42
S1PR1 P21453 5/20 0.42
S1PR3 Q99500 5/20 0.42
S1PR4 O95977 4/20 0.42
OPRM1 P35372 1/20 0.41
PLA2G1B P04054 1/20 0.41
PLA2G2A P14555 1/20 0.41
SPHK1 Q9NYA1 2/20 0.35
ALDH1A1 P00352 1/20 0.35
TP53 P04637 2/20 0.34
LAP3 P28838 2/20 0.34
CYP2D6 P10635 2/20 0.33
GMNN O75496 1/20 0.33
POLB P06746 1/20 0.33
THPO P40225 1/20 0.33
MTOR P42345 1/20 0.33
BLM P54132 1/20 0.33
KDM4E B2RXH2 1/20 0.33
CYP1A2 P05177 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10430335 0.98 LMNA (0.46) LMNAS1PR2S1PR1S1PR3S1PR4
SCHEMBL28823224 0.98 LMNA (0.46) LMNAS1PR2S1PR1S1PR3S1PR4
Hydrochloric Acid SCHEMBL7030381 0.96 LMNA (0.44) LMNAS1PR2S1PR1S1PR3S1PR4
SCHEMBL12804736 0.94 LMNA (0.40) LMNAS1PR2S1PR1S1PR3S1PR4
SCHEMBL2713877 0.90 LMNA (0.50) LMNAS1PR2S1PR1S1PR3S1PR4
SCHEMBL16447008 0.90 LMNA (0.50) LMNAS1PR2S1PR1S1PR3S1PR4
Hydrochloric Acid SCHEMBL1334525 0.89 LMNA (0.49) LMNAS1PR2S1PR1S1PR3S1PR4
Hydrochloric Acid SCHEMBL1333770 0.89 LMNA (0.49) LMNAS1PR2S1PR1S1PR3S1PR4
Hydrochloric Acid SCHEMBL7909372 0.89 LMNA (0.49) LMNAS1PR2S1PR1S1PR3S1PR4
Hydrochloric Acid SCHEMBL1123186 0.89 LMNA (0.49) LMNAS1PR2S1PR1S1PR3S1PR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140187433-A1 METHODS USING A NONLINEAR OPTICAL TECHNIQUE FOR DETECTION OF INTERACTIONS INVOLVING A CONFORMATIONAL CHANGE BIODESY, LLC (US) 2014-07-03 US disclosed
US-20140186854-A1 Method Using A Nonlinear Optical Technique for Detection of Interactions Involving A Conformational Change BIODESY, LLC (US) 2014-07-03 US disclosed
US-20140187431-A1 Method Using A Nonlinear Optical Technique for Detection of Interactions Involving A Conformational Change BIODESY, LLC (US) 2014-07-03 US disclosed
US-20140187432-A1 METHODS USING A NONLINEAR OPTICAL TECHNIQUE FOR DETECTION OF INTERACTIONS INVOLVING A CONFORMATIONAL CHANGE BIODESY, LLC (US) 2014-07-03 US disclosed
US-20140178897-A1 METHODS USING A NONLINEAR OPTICAL TECHNIQUE FOR DETECTION OF INTERACTIONS INVOLVING A CONFORMATIONAL CHANGE BIODESY, LLC (US) 2014-06-26 US disclosed
US-20140178896-A1 Method Using A Nonlinear Optical Technique for Detection of Interactions Involving A Conformational Change BLUELIGHT THERAPEUTICS, INC. 2014-06-26 US disclosed
US-8497073-B2 Method using a nonlinear optical technique for detection of interactions involving a conformational change BIODESY, LLC (US) 2013-07-30 US disclosed
US-20100120164-A1 METHOD USING A NONLINEAR OPTICAL TECHNIQUE FOR DETECTION OF INTERACTIONS INVOLVING A CONFORMATIONAL CHANGE BIODESY, LLC (US) 2010-05-13 US disclosed
EP-1576394-A4 METHOD USING A NONLINEAR OPTICAL TECHNOQUE FOR DETECTION OF INTERACTIONS INVOLVING A CONFORMATIONAL CHANGE SALAFSKY JOSHUA S (US) 2008-02-27 EP disclosed
US-20060228725-A1 Method using a nonlinear optical technique for detection of interactions involving a conformational change BIODESY LLC (US) 2006-10-12 US disclosed
EP-1364204-A1 DESIGNS OF LABELS FOR DETECTION WITH A SURFACE-SELECTIVE NONLINEAR OPTICAL TECHNIQUE Salafsky, Joshua S. (US) 2003-11-26 EP disclosed
EP-1358482-A1 METHOD AND APPARATUS USING A SURFACE-SELECTIVE NONLINEAR OPTICAL TECHNIQUE Salafsky, Joshua S. (US) 2003-11-05 EP disclosed
EP-1346064-A1 METHOD AND APPARATUS USING A SURFACE-SELECTIVE NONLINEAR OPTICAL TECHNIQUE FOR DETECTION OF PROBE-TARGET INTERACTIONS Salafsky, Joshua S. (US) 2003-09-24 EP disclosed
WO-2003064991-A2 METHOD AND APPARATUS USING A NONLINEAR OPTICAL TECHNIQUE FOR DETECTION OF PROBE-TARGET INTERACTIONS IN A FIELD SALAFSKY JOSHUA S (US) 2003-08-07 WO disclosed
US-20030148391-A1 Monitoring interactions/adjustments in physical properties between G protein-coupled receptors and binding partners using surface-selective harmonic visualization/illumination BIODESY LLC 2003-08-07 US disclosed
US-20020127563-A1 Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interactions without labels BIODESY LLC 2002-09-12 US disclosed
WO-2002061415-A1 DESIGNS OF LABELS FOR DETECTION WITH A SURFACE-SELECTIVE NONLINEAR OPTICAL TECHNIQUE SALAFSKY JOSHUA S (US) 2002-08-08 WO disclosed
US-20020094528-A1 Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interations BIODESY LLC 2002-07-18 US disclosed
WO-2002054071-A1 METHOD AND APPARATUS USING A SURFACE-SELECTIVE NONLINEAR OPTICAL TECHNIQUE SALAFSKY JOSHUA S (US) 2002-07-11 WO disclosed
WO-2002044412-A1 METHOD AND APPARATUS USING A SURFACE-SELECTIVE NONLINEAR OPTICAL TECHNIQUE FOR DETECTION OF PROBE-TARGET INTERACTIONS SALAFSKY JOHUA S (US) 2002-06-06 WO disclosed