Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lofexidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 16/20 | 0.97 |
| ▸ | ADRA2B known ✓ | P18089 | 16/20 | 0.97 |
| ▸ | ADRA2C known ✓ | P18825 | 16/20 | 0.97 |
| ▸ | HTR1A | P08908 | 2/20 | 0.97 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.97 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.97 |
| ▸ | MAOA | P21397 | 6/20 | 0.60 |
| ▸ | MAOB | P27338 | 6/20 | 0.60 |
| ▸ | NISCH | Q9Y2I1 | 5/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lofexidine SCHEMBL124601 | 1.00 | ADRA2A (0.97) | ADRA2AADRA2BADRA2CHTR1ASLC6A4 | |
| Levlofexidine SCHEMBL947241 | 0.98 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CHTR1ASLC6A4 | |
| Lofexidine SCHEMBL48960 | 0.98 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CHTR1ASLC6A4 | |
| Dexlofexidine SCHEMBL124602 | 0.98 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CHTR1ASLC6A4 | |
| Lofexidine SCHEMBL678553 | 0.97 | ADRA2A (0.97) | ADRA2AADRA2BADRA2CHTR1ASLC6A4 | |
| Lofexidine SCHEMBL22616208 | 0.97 | ADRA2A (0.97) | ADRA2AADRA2BADRA2CHTR1ASLC6A4 | |
| Lofexidine SCHEMBL22616152 | 0.91 | ADRA2A (0.85) | ADRA2AADRA2BADRA2CHTR1ASLC6A4 | |
| Lofexidine SCHEMBL22616113 | 0.91 | ADRA2A (0.85) | ADRA2AADRA2BADRA2CHTR1ASLC6A4 | |
| Lofexidine SCHEMBL22616174 | 0.91 | ADRA2A (0.85) | ADRA2AADRA2BADRA2CHTR1ASLC6A4 | |
| Lofexidine SCHEMBL22616216 | 0.90 | ADRA2A (0.82) | ADRA2AADRA2BADRA2CHTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160369237-A1 | METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY | ADVANCED CELL TECH INC (US) | 2016-12-22 | — | — | US | disclosed |
| US-20100184033-A1 | METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY | Lineage Cell Therapeutics, Inc. | 2010-07-22 | — | — | US | disclosed |
| US-20080226601-A1 | Herpes Virus-Based Compositions and Methods of Use in the Prenatal and Perinatal Periods | UNIVERSITY OF ROCHESTER (US) | 2008-09-18 | — | — | US | disclosed |
| EP-1903873-A2 | HERPES VIRUS-BASED COMPOSITIONS AND METHODS OF USE IN THE PRENATAL AND PERINATAL PERIODS | THE UNIVERSITY OF ROCHESTER (US) | 2008-04-02 | — | — | EP | disclosed |
| US-20080070303-A1 | Using myocardial and/or muscle progenitor cells as modeling tool in tissue engineering; regenerative medicine and organ replacement | ADVANCED CELL TECHNOLOGY | 2008-03-20 | — | — | US | disclosed |
| WO-2007062198-A1 | METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY | ADVANCED CELL TECHNOLOGY, INC. (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2006135602-A2 | HERPES VIRUS-BASED COMPOSITIONS AND METHODS OF USE IN THE PRENATAL AND PERINATAL PERIODS | UNIVERSITY OF ROCHESTER (US) | 2006-12-21 | — | — | WO | disclosed |