Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD1 | Q9Y239 | 5/20 | 0.41 |
| ▸ | GGT1 | P19440 | 1/20 | 0.37 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.37 |
| ▸ | TLR2 | O60603 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 5/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL350198 | 1.00 | NOD1 (0.41) | NOD1GGT1C3AR1TLR2MEN1 | |
| Hydrochloric Acid SCHEMBL26096762 | 0.98 | NOD1 (0.40) | NOD1GGT1C3AR1TLR2MEN1 | |
| SCHEMBL6429710 | 0.92 | NOD1 (0.49) | NOD1GGT1C3AR1TLR2FOLH1 | |
| SCHEMBL1343491 | 0.92 | NOD1 (0.49) | NOD1GGT1C3AR1TLR2FOLH1 | |
| Benzene SCHEMBL28171540 | 0.92 | C3AR1 (0.38) | NOD1GGT1C3AR1TLR2ITGB3 | |
| SCHEMBL5983126 | 0.91 | NOD1 (0.51) | NOD1TLR2ITGB3ITGA2BFOLH1 | |
| SCHEMBL5983133 | 0.91 | NOD1 (0.51) | NOD1TLR2ITGB3ITGA2BFOLH1 | |
| SCHEMBL25334014 | 0.90 | NOD1 (0.53) | NOD1TLR2FOLH1DPP7FNTA | |
| SCHEMBL7029222 | 0.90 | NOD1 (0.53) | NOD1TLR2FOLH1DPP7FNTA | |
| SCHEMBL8664762 | 0.90 | NOD1 (0.53) | NOD1TLR2FOLH1DPP7FNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922454-B1 | Arginine antagonists for inhibition of systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor | UNIV TEXAS (US) | 2005-11-16 | — | — | EP | claimed |
| EP-0592557-B1 | NITRIC OXIDE SYNTHESIS INHIBITORS FOR POTENTIATING THE ACTION OF PRESSOR AGENTS IN CERTAIN HYPOTENSIVE PATIENTS | UNIV TEXAS (US) | 2000-02-02 | — | — | EP | claimed |
| EP-0922454-A2 | Arginine antagonists for inhibition of systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor | Board of Regents, The University of Texas System (US) | 1999-06-16 | — | — | EP | claimed |
| EP-0597831-B1 | ARGININE ANTAGONISTS FOR INHIBITION OF SYSTEMIC HYPOTENSION ASSOCIATED WITH NITRIC OXIDE PRODUCTION OR ENDOTHELIAL DERIVED RELAXING FACTOR | UNIV TEXAS (US) | 1999-01-20 | — | — | EP | claimed |
| WO-1995015753-A1 | OVULATION CONTROL BY REGULATING NITRIC OXIDE LEVELS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1995-06-15 | — | — | WO | claimed |
| EP-3210998-A1 | METASTIN DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2017-08-30 | — | — | EP | disclosed |
| EP-2314609-B1 | METASTIN DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2016-11-30 | — | — | EP | disclosed |
| EP-2113513-B1 | Metastin derivatives and use thereof | TAKEDA PHARMACEUTICAL (JP) | 2016-05-18 | — | — | EP | disclosed |
| EP-2081955-B1 | METASTIN DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2015-05-06 | — | — | EP | disclosed |
| US-8778871-B2 | Metastin derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-07-15 | — | — | US | disclosed |
| US-8765909-B2 | Metastin derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-07-01 | — | — | US | disclosed |
| EP-1577323-B1 | METASTIN DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2013-07-10 | — | — | EP | disclosed |
| EP-0649303-A4 | SUBSTITUTED ARGININES AND SUBSTITUTED HOMOARGININES AND USE THEREOF. | CORNELL RES FOUNDATION INC (US) | 1995-07-05 | — | — | EP | disclosed |
| WO-1995015753-A1 | OVULATION CONTROL BY REGULATING NITRIC OXIDE LEVELS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1995-06-15 | — | — | WO | disclosed |
| EP-0649303-A1 | SUBSTITUTED ARGININES AND SUBSTITUTED HOMOARGININES AND USE THEREOF | CORNELL RESEARCH FOUNDATION, INC. (US) | 1995-04-26 | — | — | EP | disclosed |
| WO-1993024126-A1 | SUBSTITUTED ARGININES AND SUBSTITUTED HOMOARGININES AND USE THEREOF | CORNELL RESEARCH FOUNDATION, INC. (US) | 1993-12-09 | — | — | WO | disclosed |
| EP-0346460-B1 | PURINE DERIVATIVES HAVING PHARMACOLOGICAL ACTION | CO PHARMA CORPORATION (IT) | 1993-03-10 | — | — | EP | disclosed |
| US-5110798-A | Immunomodulators for bone marrow transplants | CO PHARMA CORPORATION S.R.L. (IT) | 1992-05-05 | — | — | US | disclosed |
| EP-0346460-A1 | PURINE DERIVATIVES HAVING PHARMACOLOGICAL ACTION. | CO PHARMA CORP SRL (IT) | 1989-12-20 | — | — | EP | disclosed |
| WO-1989005818-A1 | PURINE DERIVATIVES HAVING PHARMACOLOGICAL ACTION | CO PHARMA CORPORATION S.R.L. (IT) | 1989-06-29 | — | — | WO | disclosed |