Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 1.00 |
| ▸ | PDGFRB | P09619 | 3/20 | 1.00 |
| ▸ | FGFR1 | P11362 | 3/20 | 1.00 |
| ▸ | NPC1 | O15118 | 9/20 | 0.61 |
| ▸ | RAB9A | P51151 | 9/20 | 0.61 |
| ▸ | GBA1 | P04062 | 1/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3502278 | 0.86 | KDR (0.74) | KDRPDGFRBFGFR1NPC1RAB9A | |
| SCHEMBL6159118 | 0.86 | KDR (0.74) | KDRPDGFRBFGFR1NPC1RAB9A | |
| SCHEMBL4300569 | 0.86 | KDR (0.74) | KDRPDGFRBFGFR1NPC1RAB9A | |
| SCHEMBL7084245 | 0.86 | FGFR1 (0.74) | KDRPDGFRBFGFR1NPC1RAB9A | |
| SCHEMBL6159113 | 0.86 | KDR (0.74) | KDRPDGFRBFGFR1NPC1RAB9A | |
| SCHEMBL6158992 | 0.86 | KDR (0.74) | KDRPDGFRBFGFR1NPC1RAB9A | |
| SCHEMBL3500603 | 0.86 | KDR (0.74) | KDRPDGFRBFGFR1NPC1RAB9A | |
| SCHEMBL3502903 | 0.86 | KDR (0.74) | KDRPDGFRBFGFR1NPC1RAB9A | |
| SCHEMBL4298828 | 0.86 | KDR (0.74) | KDRPDGFRBFGFR1NPC1RAB9A | |
| SCHEMBL3501686 | 0.86 | KDR (0.74) | KDRPDGFRBFGFR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110055056-A | The quinolinones fluorescence probe and its preparation method and application that benzimidazolyl replaces | 三峡大学 | 2019-07-26 | — | — | CN | claimed |
| CN-101223157-B | Process for the synthesis of heterocyclic compounds | NOVARTIS AG | 2013-03-06 | — | — | CN | claimed |
| CN-1878766-B | Methods for synthesizing quinolinone compounds | NOVARTIS VACCINES & DIAGNOSTIC | 2011-08-17 | — | — | CN | claimed |
| CN-101223157-A | Process for the synthesis of heterocyclic compounds | NOVARTIS AG (CH) | 2008-07-16 | — | — | CN | claimed |
| CN-1878766-A | Methods for synthesizing quinolinone compounds | CHIRON CORP (US) | 2006-12-13 | — | — | CN | claimed |
| CN-105622574-A | 3-benzimidazole-2(1H)-quinolinone derivative and preparation method and application thereof | GUILIN NORMAL COLLEGE | 2016-06-01 | — | — | CN | disclosed |
| CN-105622574-A | 3-benzimidazole-2(1H)-quinolinone derivative and preparation method and application thereof | GUILIN NORMAL COLLEGE | 2016-06-01 | — | — | CN | disclosed |
| CN-101223157-B | Process for the synthesis of heterocyclic compounds | NOVARTIS AG | 2013-03-06 | — | — | CN | disclosed |
| CN-1878766-B | Methods for synthesizing quinolinone compounds | NOVARTIS VACCINES & DIAGNOSTIC | 2011-08-17 | — | — | CN | disclosed |
| US-20100184754-A1 | QUINOLINONE DERIVATIVES | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2010-07-22 | — | — | US | disclosed |
| US-20090281100-A1 | Benzimidazole quinolinones and uses thereof | BARSANTI PAUL A | 2009-11-12 | — | — | US | disclosed |
| US-7598268-B2 | Quinolinone derivatives | NOVARTIS VACCINES & DIAGNOSTICS, INC. (US) | 2009-10-06 | — | — | US | disclosed |
| US-20050209456-A1 | Vascular endothelial growth factor; tyrosine kinase inhibitor; angiogenesis inhibitor; anticancer agents | CHIRON CORPORATION | 2005-09-22 | — | — | US | disclosed |
| US-20050054672-A1 | Vascular endothelial growth factor; tyrosine kinase inhibitor;angiogenesis inhibitor; anticarcinogenic agents | CHIRON CORPORATION | 2005-03-10 | — | — | US | disclosed |
| US-6822097-B1 | THIAZOLE-SUBSTITUTED QUINOLINE DERIVATIVES; ANTICARCINOGENIC AGENTS, ANTISTROKE AGENTS; APOPTOSIS AND CELL PROLIFERATION TREATMENT; NERVOUS SYSTEM DISORDERS | AMGEN, INC. | 2004-11-23 | — | — | US | disclosed |
| US-6800760-B2 | INHIBITORS OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR TYROSINE KINASE | CHIRON CORPORATION | 2004-10-05 | — | — | US | disclosed |
| US-6774237-B2 | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR TYROSINE KINASES INHIBITORS; ANGIOGENESIS INHIBITORS, ANTICARCINOGENIC AGENTS | CHIRON CORPORATION | 2004-08-10 | — | — | US | disclosed |
| US-6762194-B2 | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR TYROSINE KINASE INHIBITORS | CHIRON CORPORATION | 2004-07-13 | — | — | US | disclosed |
| US-6605617-B2 | Treating a patient in need of an inhibitor of vascular endothelial growth factor receptor tyrosine kinase | CHIRON CORPORATION | 2003-08-12 | — | — | US | disclosed |
| US-6479512-B1 | TO TREAT TYROSINE KINASE-DEPENDENT DISEASES AND CONDITIONS, SUCH AS ANGIOGENESIS, CANCER, TUMOR GROWTH, ATHEROSCLEROSIS, AGE RELATED MACULAR DEGENERATION, DIABETIC RETINOPATHY, INFLAMMATORY DISEASES, ETC. | MERCK & CO., INC. | 2002-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281100-A1 | Benzimidazole quinolinones and uses thereof | GAA, ALPI, IL4I1 | KDR 4671/4885PDGFRB 3508/4885FGFR1 3018/4885 |
| US-20050054672-A1 | Vascular endothelial growth factor; tyrosine kinase inhibitor;angiogenesis inhibitor; anticarcinogenic agents | VEGFA, FLT1, KDR | KDR 3/4885PDGFRB 49/4885FGFR1 10/4885 |
| US-20050209456-A1 | Vascular endothelial growth factor; tyrosine kinase inhibitor; angiogenesis inhibitor; anticancer agents | KDR, FLT4, FLT1 | KDR 1/4885PDGFRB 26/4885FGFR1 23/4885 |
| US-20100184754-A1 | QUINOLINONE DERIVATIVES | SLCO1B1, SLCO1B3, SLCO1A2 | KDR 4147/4885PDGFRB 4032/4885FGFR1 2959/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.