Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 12/20 | 0.58 |
| ▸ | MAOA | P21397 | 3/20 | 0.48 |
| ▸ | BCHE | P06276 | 6/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8792259 | 0.98 | ACHE (0.56) | ACHEMAOABCHETAAR1NPC1 | |
| Hydrochloric Acid SCHEMBL8792264 | 0.98 | ACHE (0.56) | ACHEMAOABCHETAAR1NPC1 | |
| SCHEMBL3506521 | 0.91 | ACHE (0.48) | ACHEMAOATAAR1NPC1GAA | |
| SCHEMBL3508486 | 0.91 | ACHE (0.55) | ACHEMAOABCHE | |
| Hydrochloric Acid SCHEMBL8792518 | 0.90 | ACHE (0.47) | ACHEMAOATAAR1NPC1GAA | |
| Hydrochloric Acid SCHEMBL8792511 | 0.90 | ACHE (0.47) | ACHEMAOATAAR1NPC1GAA | |
| Fumaric Acid SCHEMBL8794233 | 0.87 | ACHE (0.51) | ACHEMAOABCHE | |
| Maleic Acid SCHEMBL8794229 | 0.87 | ACHE (0.51) | ACHEMAOABCHE | |
| Hydrochloric Acid SCHEMBL9260785 | 0.85 | ACHE (0.47) | ACHENPC1RAB9ABRD4CREBBP | |
| SCHEMBL9269605 | 0.84 | BCHE (0.45) | ACHEBCHETAAR1NPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5100891-A | Antidepressants | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-03-31 | — | — | US | claimed |
| US-20100247543-A1 | TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES | ORYZON GENOMICS, S.A. (ES) | 2010-09-30 | — | — | US | disclosed |
| EP-2195029-A2 | TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES | Oryzon Genomics SA (ES) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009027349-A2 | TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES | ORYZON GENOMICS SA (ES) | 2009-03-05 | — | — | WO | disclosed |