Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8793697 | 0.85 | MAPK1 (0.56) | HRH3KDM4EHSD17B10ALDH1A1TSHR | |
| SCHEMBL9669207 | 0.85 | MAPK1 (0.56) | HRH3KDM4EHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL3504393 | 0.85 | MAPK1 (0.56) | HRH3KDM4EHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL19002614 | 0.84 | HRH3 (0.58) | HRH3KDM4EHSD17B10ALDH1A1TSHR | |
| SCHEMBL3507895 | 0.83 | DPP8 (0.57) | HRH3KDM4EHSD17B10ALDH1A1TSHR | |
| SCHEMBL11743606 | 0.81 | KMT2A (0.58) | KDM4EHSD17B10ALDH1A1TSHRMAPK1 | |
| SCHEMBL30133462 | 0.81 | KMT2A (0.58) | KDM4EHSD17B10ALDH1A1TSHRMAPK1 | |
| SCHEMBL3504748 | 0.81 | KMT2A (0.58) | KDM4EHSD17B10ALDH1A1TSHRMAPK1 | |
| SCHEMBL10799287 | 0.81 | HRH3 (0.62) | HRH3KDM4EHSD17B10ALDH1A1TSHR | |
| SCHEMBL3504123 | 0.79 | KMT2A (0.60) | KDM4EHSD17B10ALDH1A1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100217003-A1 | 1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES HAVING EFFECTS OF PREVENTING AND TREATING DEGENERATIVE AND INFLAMMATORY DISEASES | UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION (KR) | 2010-08-26 | — | — | US | disclosed |
| EP-2117547-A1 | 1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES HAVING EFFECTS OF PREVENTING AND TREATING DEGENERATIVE AND INFLAMMATORY DISEASES | University Of Ulsan Foundation For Industry Cooperation (KR) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008069632-A1 | 1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES HAVING EFFECTS OF PREVENTING AND TREATING DEGENERATIVE AND INFLAMMATORY DISEASES | UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION (KR) | 2008-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100217003-A1 | 1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES HAVING EFFECTS OF PREVENTING AND TREATING DEGENERATIVE AND INFLAMMATORY DISEASES | NFKBIA, HMOX1, PTGS1 | HRH3 1244/4885KDM4E 626/4885HSD17B10 553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.