Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 1.00 |
| ▸ | PDPK1 | O15530 | 2/20 | 1.00 |
| ▸ | CYTH3 | O43739 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17897768 | 0.89 | AKT1 (0.80) | AKT1PDPK1CYTH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL15778848 | 0.85 | PDPK1 (0.73) | AKT1PDPK1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL17897759 | 0.85 | PDPK1 (0.73) | AKT1PDPK1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL15777497 | 0.84 | AKT1 (0.73) | AKT1PDPK1CYTH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL17897758 | 0.84 | AKT1 (0.73) | AKT1PDPK1CYTH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL15778299 | 0.84 | AKT1 (0.72) | AKT1PDPK1CYTH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL14859594 | 0.83 | AKT1 (0.71) | AKT1PDPK1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL15778850 | 0.82 | AKT1 (0.70) | AKT1PDPK1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL15777371 | 0.81 | AKT1 (0.68) | AKT1PDPK1CYTH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL352191 | 0.78 | AKT1 (1.00) | AKT1PDPK1CYTH3ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160194279-A1 | ONE POT PROCESS FOR THE CONVERSION OF AROYL CHLORIDES TO ACYL THIOUREAS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-07-07 | — | — | US | claimed |
| US-20160194279-A1 | ONE POT PROCESS FOR THE CONVERSION OF AROYL CHLORIDES TO ACYL THIOUREAS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-07-07 | — | — | US | disclosed |
| US-20160194279-A1 | ONE POT PROCESS FOR THE CONVERSION OF AROYL CHLORIDES TO ACYL THIOUREAS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-07-07 | — | — | US | disclosed |
| US-20160194279-A1 | ONE POT PROCESS FOR THE CONVERSION OF AROYL CHLORIDES TO ACYL THIOUREAS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-07-07 | — | — | US | disclosed |
| US-9040585-B2 | Small molecule antagonists of phosphatidylinositol-3,4,5-triphosphate (PIP3) and uses thereof | TUFTS UNIVERSITY (US) | 2015-05-26 | — | — | US | disclosed |
| US-20140187639-A1 | Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2014-07-03 | — | — | US | disclosed |
| WO-2014087431-A1 | ONE POT PROCESS FOR THE CONVERSION OF AROYL CHLORIDES TO ACYL THIOUREAS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-06-12 | — | — | WO | disclosed |
| US-8628961-B2 | Small molecule antagonists of phosphatidylinositol-3,4,5-triphosphate (PIP3) and uses thereof | TUFTS UNIVERSITY (US) | 2014-01-14 | — | — | US | disclosed |
| US-20120016033-A1 | Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120016033-A1 | Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof | PIP5K1A, PIP5K1B, PIP4K2A | AKT1 68/4885PDPK1 61/4885CYTH3 109/4885 |
| US-20160194279-A1 | ONE POT PROCESS FOR THE CONVERSION OF AROYL CHLORIDES TO ACYL THIOUREAS | TRRAP, NAT1, AHR | AKT1 2603/4885PDPK1 4430/4885CYTH3 2061/4885 |
| US-20140187639-A1 | Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof | PIP5K1A, PIP5K1B, PIP4K2A | AKT1 68/4885PDPK1 61/4885CYTH3 109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.