Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 8/20 | 1.00 |
| ▸ | PIK3CA | P42336 | 2/20 | 1.00 |
| ▸ | PIK3CD | O00329 | 1/20 | 1.00 |
| ▸ | PIK3CB | P42338 | 1/20 | 1.00 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4534987 | 0.82 | PIK3CG (1.00) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL4523388 | 0.82 | PIK3CG (0.69) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL4523379 | 0.82 | PIK3CG (0.69) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL5960477 | 0.81 | PIK3CG (0.73) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL16882665 | 0.81 | PIK3CG (0.73) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL4523664 | 0.81 | PI4KB (0.74) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL2833123 | 0.80 | PIK3CG (0.71) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL29089046 | 0.80 | PIK3CG (0.74) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL4528096 | 0.79 | PI4KB (0.69) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL2837166 | 0.79 | PIK3CG (0.74) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298286-A1 | Organic Compounds | NOVARTIS AG | 2010-11-25 | — | — | US | disclosed |
| EP-2238134-A2 | BIS-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | Novartis AG (CH) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009080705-A2 | BIS-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | NOVARTIS AG (CH) | 2009-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298286-A1 | Organic Compounds | PIK3CA, PI4KB, PIK3CB | PIK3CG 9/4885PIK3CA 1/4885PIK3CD 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.