Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.80 |
| ▸ | HPGD | P15428 | 1/20 | 0.80 |
| ▸ | CASP1 | P29466 | 1/20 | 0.80 |
| ▸ | CASP7 | P55210 | 1/20 | 0.80 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.80 |
| ▸ | NPC1 | O15118 | 8/20 | 0.75 |
| ▸ | RAB9A | P51151 | 6/20 | 0.75 |
| ▸ | GAA | P10253 | 6/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.75 |
| ▸ | USP2 | O75604 | 3/20 | 0.75 |
| ▸ | CLK1 | P49759 | 2/20 | 0.75 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.75 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 10/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.64 |
| ▸ | POLB | P06746 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16440426 | 0.89 | TRPV4 (1.00) | MAPTSMN1; SMN2KDM4EHPGDCASP1 | |
| SCHEMBL29170022 | 0.86 | NPC1 (1.00) | MAPTSMN1; SMN2KDM4EHPGDTRPV4 | |
| SCHEMBL4515507 | 0.85 | PIK3CG (0.72) | MAPTSMN1; SMN2KDM4EHPGDCASP1 | |
| SCHEMBL4528884 | 0.84 | PIK3CG (0.84) | MAPTSMN1; SMN2KDM4EHPGDCASP1 | |
| SCHEMBL4515503 | 0.83 | PIK3CG (0.72) | MAPTSMN1; SMN2KDM4EHPGDCASP1 | |
| SCHEMBL16434487 | 0.82 | MEN1 (0.80) | MAPTSMN1; SMN2KDM4ETRPV4NPC1 | |
| SCHEMBL3511282 | 0.82 | PIK3CG (1.00) | MAPTSMN1; SMN2KDM4EHPGDCASP1 | |
| SCHEMBL17128088 | 0.80 | MAPT (0.67) | MAPTSMN1; SMN2KDM4EHPGDCASP1 | |
| SCHEMBL18281285 | 0.78 | MEN1 (1.00) | MAPTSMN1; SMN2KDM4EHPGDTRPV4 | |
| SCHEMBL7554938 | 0.77 | MAPT (0.91) | MAPTSMN1; SMN2KDM4EHPGDCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8940771-B2 | Organic compounds | NOVARTIS AG (CH) | 2015-01-27 | — | — | US | disclosed |
| EP-2240475-B1 | THIAZOLE DERIVATIVES USED AS PI 3 KINASE INHIBITORS | NOVARTIS AG (CH) | 2013-09-25 | — | — | EP | disclosed |
| US-20100298286-A1 | Organic Compounds | NOVARTIS AG | 2010-11-25 | — | — | US | disclosed |
| EP-2240475-A1 | THIAZOLE DERIVATIVES USED AS PI 3 KINASE INHIBITORS | Novartis AG (CH) | 2010-10-20 | — | — | EP | disclosed |
| EP-2238134-A2 | BIS-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | Novartis AG (CH) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009080694-A1 | THIAZOLE DERIVATIVES USED AS PI 3 KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009080705-A2 | BIS-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | NOVARTIS AG (CH) | 2009-07-02 | — | — | WO | disclosed |
| US-20090163469-A1 | Organic Compounds | NOVARTIS AG | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298286-A1 | Organic Compounds | PIK3CA, PI4KB, PIK3CB | MAPT 980/4885SMN1; SMN2 2765/4885KDM4E 2526/4885 |
| US-20090163469-A1 | Organic Compounds | PIK3C3, PIK3CA, PIK3CD | MAPT 1124/4885SMN1; SMN2 4701/4885KDM4E 2761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.