Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 16/20 | 0.75 |
| ▸ | INSR | P06213 | 15/20 | 0.75 |
| ▸ | IGF1R | P08069 | 12/20 | 0.75 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.75 |
| ▸ | AURKA | O14965 | 3/20 | 0.75 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.75 |
| ▸ | FLT3 | P36888 | 3/20 | 0.64 |
| ▸ | PLK4 | O00444 | 2/20 | 0.64 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.64 |
| ▸ | PRKCG | P05129 | 2/20 | 0.64 |
| ▸ | ROS1 | P08922 | 2/20 | 0.64 |
| ▸ | FER | P16591 | 2/20 | 0.64 |
| ▸ | LTK | P29376 | 2/20 | 0.64 |
| ▸ | FRK | P42685 | 2/20 | 0.64 |
| ▸ | MST1R | Q04912 | 2/20 | 0.64 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.64 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.64 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.64 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1334182 | 0.88 | KIT (0.64) | ALKINSRIGF1RNTRK1AURKA | |
| SCHEMBL28917625 | 0.88 | INSR (0.68) | ALKINSRIGF1RNTRK1AURKA | |
| SCHEMBL3514038 | 0.87 | ALK (0.79) | ALKINSRIGF1RNTRK1AURKA | |
| SCHEMBL3513299 | 0.86 | INSR (0.83) | ALKINSRIGF1RNTRK1AURKA | |
| SCHEMBL3511212 | 0.86 | ALK (1.00) | ALKINSRIGF1RNTRK1AURKA | |
| SCHEMBL1335086 | 0.85 | NTRK1 (0.74) | ALKINSRIGF1RNTRK1AURKA | |
| SCHEMBL29763783 | 0.84 | ALK (0.72) | ALKINSRIGF1RNTRK1AURKA | |
| SCHEMBL3510936 | 0.84 | ALK (1.00) | ALKINSRIGF1RNTRK1AURKA | |
| SCHEMBL3515047 | 0.84 | ALK (0.72) | ALKINSRIGF1RNTRK1AURKA | |
| SCHEMBL3510762 | 0.84 | INSR (0.79) | ALKINSRIGF1RNTRK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292207-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-11-18 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292207-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | MAP3K19, MAP3K3, MAP3K5 | ALK 401/4885INSR 387/4885IGF1R 188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.