Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.57 |
| ▸ | SMPD3 | Q9NY59 | 3/20 | 0.55 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.52 |
| ▸ | ERN1 | O75460 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 2/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 5/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3513237 | 0.94 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CBPIK3CGSMPD3 | |
| SCHEMBL14013987 | 0.90 | PIK3CA (0.47) | PIK3CDPIK3CAPIK3CBPIK3CGSMPD3 | |
| SCHEMBL3513209 | 0.89 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3CBPIK3CGSMPD3 | |
| SCHEMBL4062318 | 0.88 | SMPD3 (0.60) | PIK3CDPIK3CAPIK3CBPIK3CGSMPD3 | |
| SCHEMBL3513076 | 0.87 | NOS1 (0.44) | PIK3CDPIK3CAPIK3CBPIK3CGSMPD3 | |
| SCHEMBL3513947 | 0.82 | SMPD3 (0.62) | PIK3CDPIK3CAPIK3CBPIK3CGSMPD3 | |
| SCHEMBL27782941 | 0.82 | PIK3CA (0.53) | PIK3CDPIK3CAPIK3CBPIK3CGSMPD3 | |
| Tert-Butyl Formate SCHEMBL27782943 | 0.82 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGSMPD3 | |
| SCHEMBL3514744 | 0.81 | PIK3CA (0.66) | PIK3CDPIK3CAPIK3CBPIK3CGFYN | |
| SCHEMBL3512458 | 0.81 | PIK3CA (0.69) | PIK3CDPIK3CAPIK3CBPIK3CGFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305113-A1 | Substituted Imidazopyridazines as Lipid Kinase Inhibitors | CAPRARO HANS-GEORG | 2010-12-02 | — | — | US | claimed |
| US-20100305113-A1 | Substituted Imidazopyridazines as Lipid Kinase Inhibitors | CAPRARO HANS-GEORG | 2010-12-02 | — | — | US | disclosed |
| US-20100305113-A1 | Substituted Imidazopyridazines as Lipid Kinase Inhibitors | CAPRARO HANS-GEORG | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305113-A1 | Substituted Imidazopyridazines as Lipid Kinase Inhibitors | PI4KA, PIK3CA, PIK3CB | PIK3CD 4/4885PIK3CA 2/4885PIK3CB 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.