⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16085873 | 0.88 | UGT2B7 (0.33) | — | |
| SCHEMBL14665205 | 0.77 | F10 (0.33) | — | |
| SCHEMBL11037298 | 0.76 | — | — | |
| SCHEMBL14665204 | 0.76 | ARG1 (0.33) | — | |
| SCHEMBL22588562 | 0.75 | — | — | |
| SCHEMBL6130714 | 0.74 | — | — | |
| SCHEMBL27849766 | 0.73 | — | — | |
| SCHEMBL22519804 | 0.73 | — | — | |
| SCHEMBL22519837 | 0.73 | — | — | |
| SCHEMBL16085911 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225765-A2 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| CN-116601158-A | Modulators of cystic fibrosis transmembrane conductance regulator | 弗特克斯药品有限公司 | 2023-08-15 | — | — | CN | disclosed |
| WO-2022076622-A2 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |
| WO-2022076622-A2 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |
| US-10336660-B2 | Stabilized DCD and/or alkyl thiophosphoric triamide solvent systems and use in agricultural applications | RHODIA OPERATIONS (FR) | 2019-07-02 | — | — | US | disclosed |
| CN-103917509-B | Process for producing alkanediol | 宇部兴产株式会社 | 2016-08-31 | — | — | CN | disclosed |
| US-9051234-B2 | Method for producing alkanediol | UBE INDUSTRIES, LTD. (JP) | 2015-06-09 | — | — | US | disclosed |
| US-20140316167-A1 | METHOD FOR PRODUCING ALKANEDIOL | UBE INDUSTRIES, LTD (JP) | 2014-10-23 | — | — | US | disclosed |
| EP-2781498-A1 | METHOD FOR PRODUCING ALKANEDIOL | Ube Industries, Ltd. (JP) | 2014-09-24 | — | — | EP | disclosed |
| CN-103917509-A | Process for producing alkanediol | UBE INDUSTRIES | 2014-07-09 | — | — | CN | disclosed |
| US-20100222387-A1 | 3-Fluoro-Piperidine T-Type Calcium Channel Antagonists | MERCK SHARP & DOHME CORP. | 2010-09-02 | — | — | US | disclosed |
| EP-1896414-A4 | 3-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO INC (US) | 2009-09-09 | — | — | EP | disclosed |
| EP-1896414-A2 | 3-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | Merck & Co., Inc. (US) | 2008-03-12 | — | — | EP | disclosed |
| WO-2007002361-A2 | 3-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2007-01-04 | — | — | WO | disclosed |