Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.54 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.50 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8852978 | 0.86 | AURKA (0.53) | AURKAPARP1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL4518985 | 0.86 | AURKA (0.53) | AURKAPARP1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL11157630 | 0.83 | AURKA (0.53) | AURKAPARP1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL4074442 | 0.83 | AURKA (0.53) | AURKAPARP1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL27651961 | 0.83 | AURKA (0.53) | AURKAPARP1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL822253 | 0.82 | FTO (0.50) | AURKAPARP1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL1063233 | 0.79 | KDM5A (0.62) | KDM4EMAPTMEN1KMT2AKDM5A | |
| SCHEMBL16497485 | 0.79 | AURKA (0.46) | AURKAPARP1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL13598062 | 0.78 | MEN1 (0.59) | AURKAPARP1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL11407079 | 0.77 | AURKA (0.47) | AURKAPARP1GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102015705-B | Fused heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL | 2013-11-13 | — | — | CN | disclosed |
| CN-102015705-A | Fused heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL | 2011-04-13 | — | — | CN | disclosed |
| US-20100056563-A1 | NOVEL 1.8-NAPHTHYRIDINE COMPOUNDS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
| US-4128649-A | ANTIALLERGEN | SANDOZ, INC. (US) | 1978-12-05 | — | — | US | disclosed |
| US-4128649-A | ANTIALLERGEN | SANDOZ, INC. (US) | 1978-12-05 | — | — | US | disclosed |
| US-4128649-A | ANTIALLERGEN | SANDOZ, INC. (US) | 1978-12-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056563-A1 | NOVEL 1.8-NAPHTHYRIDINE COMPOUNDS | HIF1AN, HIF1A, EGLN2 | AURKA 2388/4885PARP1 585/4885GRIN2D 4799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.