Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 9/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 1/20 | 0.70 |
| ▸ | JAK2 | O60674 | 5/20 | 0.58 |
| ▸ | TYK2 | P29597 | 3/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | BCR | P11274 | 1/20 | 0.54 |
| ▸ | PRKCA | P17252 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.53 |
| ▸ | RHOA | P61586 | 1/20 | 0.51 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3516179 | 0.89 | AURKA (0.68) | AURKANPC1RAB9AJAK2TYK2 | |
| SCHEMBL3515247 | 0.88 | JAK2 (0.64) | AURKANPC1RAB9AJAK2TYK2 | |
| SCHEMBL3514256 | 0.83 | JAK2 (0.54) | AURKAJAK2TYK2AURKB | |
| SCHEMBL3513072 | 0.82 | TYK2 (0.62) | AURKAJAK2TYK2AURKB | |
| SCHEMBL3513587 | 0.82 | JAK2 (0.51) | AURKANPC1RAB9AJAK2TYK2 | |
| SCHEMBL3512434 | 0.78 | JAK2 (0.54) | AURKAJAK2TYK2AURKB | |
| SCHEMBL3514123 | 0.78 | TYK2 (0.65) | AURKANPC1RAB9AJAK2TYK2 | |
| Hydrochloric Acid SCHEMBL2103616 | 0.76 | NPC1 (0.61) | NPC1RAB9AJAK2TYK2 | |
| SCHEMBL3515174 | 0.76 | PDPK1 (0.52) | AURKANPC1RAB9AJAK2TYK2 | |
| SCHEMBL14292694 | 0.76 | NPC1 (0.75) | AURKANPC1RAB9AJAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8486950-B2 | Janus kinase inhibitor compounds and methods | F. HOFFMANN-LA ROCHE AG (CH) | 2013-07-16 | — | — | US | disclosed |
| US-8486950-B2 | Janus kinase inhibitor compounds and methods | F. HOFFMANN-LA ROCHE AG (CH) | 2013-07-16 | — | — | US | disclosed |
| US-8486950-B2 | Janus kinase inhibitor compounds and methods | F. HOFFMANN-LA ROCHE AG (CH) | 2013-07-16 | — | — | US | disclosed |
| WO-2010142752-A1 | JANUS KINASE INHIBITOR COMPOUNDS AND METHODS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-12-16 | — | — | WO | disclosed |
| US-20100317643-A1 | JANUS KINASE INHIBITOR COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2010-12-16 | — | — | US | disclosed |
| US-20100317643-A1 | JANUS KINASE INHIBITOR COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2010-12-16 | — | — | US | disclosed |
| US-20100317643-A1 | JANUS KINASE INHIBITOR COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317643-A1 | JANUS KINASE INHIBITOR COMPOUNDS AND METHODS | JAK2, JAK1, JAK3 | AURKA 70/4885NPC1 2620/4885RAB9A 2583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.